Abstract
Attempts were made to design and develop an analytical pipeline for identifying ways ofincreasing the production of a target metabolite that combine an optimized substrate-feedingschedule with a strategy for identifying and eliminating bottlenecks in metabolic pathways. Asa case study, the proposed analytical pipeline was applied to acetone-butanol-ethanolfermentation by Clostridium bacteria, a process that has attracted considerable attention as ametabolic system capable of producing butanol, a possible biofuel.
| Original language | English |
|---|---|
| Pages (from-to) | 1-23 |
| Number of pages | 23 |
| Journal | Chem-Bio Informatics Journal |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2011 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
Cite this
Development of an analytical pipeline for optimizing substrate feeding and eliminating metabolic bottlenecks. / Kuriya, Yuki; Tanaka, Shigemitsu; Kobayashi, Genta; Hanai, Taizo; Okamoto, Masahiro.
In: Chem-Bio Informatics Journal, Vol. 11, No. 1, 01.01.2011, p. 1-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of an analytical pipeline for optimizing substrate feeding and eliminating metabolic bottlenecks
AU - Kuriya, Yuki
AU - Tanaka, Shigemitsu
AU - Kobayashi, Genta
AU - Hanai, Taizo
AU - Okamoto, Masahiro
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Attempts were made to design and develop an analytical pipeline for identifying ways ofincreasing the production of a target metabolite that combine an optimized substrate-feedingschedule with a strategy for identifying and eliminating bottlenecks in metabolic pathways. Asa case study, the proposed analytical pipeline was applied to acetone-butanol-ethanolfermentation by Clostridium bacteria, a process that has attracted considerable attention as ametabolic system capable of producing butanol, a possible biofuel.
AB - Attempts were made to design and develop an analytical pipeline for identifying ways ofincreasing the production of a target metabolite that combine an optimized substrate-feedingschedule with a strategy for identifying and eliminating bottlenecks in metabolic pathways. Asa case study, the proposed analytical pipeline was applied to acetone-butanol-ethanolfermentation by Clostridium bacteria, a process that has attracted considerable attention as ametabolic system capable of producing butanol, a possible biofuel.
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UR - http://www.scopus.com/inward/citedby.url?scp=79960221396&partnerID=8YFLogxK
U2 - 10.1273/cbij.11.1
DO - 10.1273/cbij.11.1
M3 - Article
VL - 11
SP - 1
EP - 23
JO - Chem-Bio Informatics Journal
JF - Chem-Bio Informatics Journal
SN - 1347-6297
IS - 1
ER -