Development of an analytical pipeline for optimizing substrate feeding and eliminating metabolic bottlenecks

Yuki Kuriya, Shigemitsu Tanaka, Genta Kobayashi, Taizo Hanai, Masahiro Okamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Attempts were made to design and develop an analytical pipeline for identifying ways ofincreasing the production of a target metabolite that combine an optimized substrate-feedingschedule with a strategy for identifying and eliminating bottlenecks in metabolic pathways. Asa case study, the proposed analytical pipeline was applied to acetone-butanol-ethanolfermentation by Clostridium bacteria, a process that has attracted considerable attention as ametabolic system capable of producing butanol, a possible biofuel.

Original languageEnglish
Pages (from-to)1-23
Number of pages23
JournalChem-Bio Informatics Journal
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

Fingerprint

Butanols
Pipelines
Clostridium
Biofuels
Substrates
Metabolites
Acetone
Metabolic Networks and Pathways
Bacteria

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Development of an analytical pipeline for optimizing substrate feeding and eliminating metabolic bottlenecks. / Kuriya, Yuki; Tanaka, Shigemitsu; Kobayashi, Genta; Hanai, Taizo; Okamoto, Masahiro.

In: Chem-Bio Informatics Journal, Vol. 11, No. 1, 01.01.2011, p. 1-23.

Research output: Contribution to journalArticle

Kuriya, Yuki ; Tanaka, Shigemitsu ; Kobayashi, Genta ; Hanai, Taizo ; Okamoto, Masahiro. / Development of an analytical pipeline for optimizing substrate feeding and eliminating metabolic bottlenecks. In: Chem-Bio Informatics Journal. 2011 ; Vol. 11, No. 1. pp. 1-23.
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