Development of an analytical pipeline for optimizing substrate feeding and eliminating metabolic bottlenecks

Yuki Kuriya, Shigemitsu Tanaka, Genta Kobayashi, Taizo Hanai, Masahiro Okamoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Attempts were made to design and develop an analytical pipeline for identifying ways ofincreasing the production of a target metabolite that combine an optimized substrate-feedingschedule with a strategy for identifying and eliminating bottlenecks in metabolic pathways. Asa case study, the proposed analytical pipeline was applied to acetone-butanol-ethanolfermentation by Clostridium bacteria, a process that has attracted considerable attention as ametabolic system capable of producing butanol, a possible biofuel.

Original languageEnglish
Pages (from-to)1-23
Number of pages23
JournalChem-Bio Informatics Journal
Volume11
Issue number1
DOIs
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry

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