Development of an artificial lipid-based membrane sensor with high selectivity and sensitivity to the bitterness of drugs and with high correlation with sensory score

Yoshikazu Kobayashi, Hikari Hamada, Yasuhiro Yamaguchi, Hidekazu Ikezaki, Kiyoshi Toko

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This paper reports the development of membrane sensors based on an artificial lipid and plasticizers with high selectivity and sensitivity to drug bitterness by using bis(1-butylpentyl) adipate (BBPA), bis(2-ethylhexyl) sebacate (BEHS), phosphoric acid tris(2-ethylhexyl) ester (PTEH), and tributyl o-acetylcitrate (TBAC) as a plasticizer and phosphoric acid di-n-decyl ester (PADE) as an artificial lipid to optimize surface hydrophobicity of the sensors. In addition, a sensor with highly correlated bitterness sensory score was developed by blending BBPA and TBAC to detect the bitterness suppression effect of sucrose, and other bitter-masking materials. Therefore, this sensor can be used to evaluate the bitterness of various drug formulations with high accuracy.

Original languageEnglish
Pages (from-to)710-719
Number of pages10
JournalIEEJ Transactions on Electrical and Electronic Engineering
Volume4
Issue number6
DOIs
Publication statusPublished - Nov 2009

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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