TY - JOUR
T1 - Development of an artificial lipid-based membrane sensor with high selectivity and sensitivity to the bitterness of drugs and with high correlation with sensory score
AU - Kobayashi, Yoshikazu
AU - Hamada, Hikari
AU - Yamaguchi, Yasuhiro
AU - Ikezaki, Hidekazu
AU - Toko, Kiyoshi
PY - 2009/11
Y1 - 2009/11
N2 - This paper reports the development of membrane sensors based on an artificial lipid and plasticizers with high selectivity and sensitivity to drug bitterness by using bis(1-butylpentyl) adipate (BBPA), bis(2-ethylhexyl) sebacate (BEHS), phosphoric acid tris(2-ethylhexyl) ester (PTEH), and tributyl o-acetylcitrate (TBAC) as a plasticizer and phosphoric acid di-n-decyl ester (PADE) as an artificial lipid to optimize surface hydrophobicity of the sensors. In addition, a sensor with highly correlated bitterness sensory score was developed by blending BBPA and TBAC to detect the bitterness suppression effect of sucrose, and other bitter-masking materials. Therefore, this sensor can be used to evaluate the bitterness of various drug formulations with high accuracy.
AB - This paper reports the development of membrane sensors based on an artificial lipid and plasticizers with high selectivity and sensitivity to drug bitterness by using bis(1-butylpentyl) adipate (BBPA), bis(2-ethylhexyl) sebacate (BEHS), phosphoric acid tris(2-ethylhexyl) ester (PTEH), and tributyl o-acetylcitrate (TBAC) as a plasticizer and phosphoric acid di-n-decyl ester (PADE) as an artificial lipid to optimize surface hydrophobicity of the sensors. In addition, a sensor with highly correlated bitterness sensory score was developed by blending BBPA and TBAC to detect the bitterness suppression effect of sucrose, and other bitter-masking materials. Therefore, this sensor can be used to evaluate the bitterness of various drug formulations with high accuracy.
UR - http://www.scopus.com/inward/record.url?scp=77951756545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951756545&partnerID=8YFLogxK
U2 - 10.1002/tee.20469
DO - 10.1002/tee.20469
M3 - Article
AN - SCOPUS:77951756545
SN - 1931-4973
VL - 4
SP - 710
EP - 719
JO - IEEJ Transactions on Electrical and Electronic Engineering
JF - IEEJ Transactions on Electrical and Electronic Engineering
IS - 6
ER -