Development of carbonate apatite as artificial bone substitute

Research output: Contribution to journalArticle

Abstract

Carbonate apatite (CO3Ap) that contains 6-9 wt% carbonate in apatitic structure is the composition of human bone. Unfortunately, CO3Ap cannot be sintered due to the presence of CO3. CO3Ap block was found to be fabricated based on a compositional transformation though dissolution-precipitation reaction using a precursor such as calcite block. CO3Ap block thus fabricated up-regulate the differentiation of osteoblastic cells and resorbed by the osteoclasts. As results of these response to cells, CO3Ap block demonstrate much better osteoconductivity than hydroxyapatite [HAp: Ca10(PO4)6(OH)2)] which is currently used artificial bone substitute. Also, CO3Ap block was found to be replace to new bone similar to autograft even though HAp would not replace to bone. Clinical trial of CO3Ap is now in progress, and CO3Ap will be available for its clinical use next year.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalJapanese Magazine of Mineralogical and Petrological Sciences
Volume46
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Bone Substitutes
apatite
bone
Bone
carbonate
Calcium Carbonate
Carbonates
Autografts
Durapatite
Dissolution
Cells
calcite
dissolution
Chemical analysis
carboapatite

All Science Journal Classification (ASJC) codes

  • Geochemistry and Petrology
  • Economic Geology

Cite this

Development of carbonate apatite as artificial bone substitute. / Ishikawa, Kunio.

In: Japanese Magazine of Mineralogical and Petrological Sciences, Vol. 46, No. 1, 01.01.2017, p. 42-46.

Research output: Contribution to journalArticle

@article{1c1044fa19c04407b5f1a40b2024c9e9,
title = "Development of carbonate apatite as artificial bone substitute",
abstract = "Carbonate apatite (CO3Ap) that contains 6-9 wt{\%} carbonate in apatitic structure is the composition of human bone. Unfortunately, CO3Ap cannot be sintered due to the presence of CO3. CO3Ap block was found to be fabricated based on a compositional transformation though dissolution-precipitation reaction using a precursor such as calcite block. CO3Ap block thus fabricated up-regulate the differentiation of osteoblastic cells and resorbed by the osteoclasts. As results of these response to cells, CO3Ap block demonstrate much better osteoconductivity than hydroxyapatite [HAp: Ca10(PO4)6(OH)2)] which is currently used artificial bone substitute. Also, CO3Ap block was found to be replace to new bone similar to autograft even though HAp would not replace to bone. Clinical trial of CO3Ap is now in progress, and CO3Ap will be available for its clinical use next year.",
author = "Kunio Ishikawa",
year = "2017",
month = "1",
day = "1",
doi = "10.2465/gkk.161217",
language = "English",
volume = "46",
pages = "42--46",
journal = "Japanese Magazine of Mineralogical and Petrological Sciences",
issn = "1349-7979",
publisher = "Nihon Koubutsu Gakkai",
number = "1",

}

TY - JOUR

T1 - Development of carbonate apatite as artificial bone substitute

AU - Ishikawa, Kunio

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Carbonate apatite (CO3Ap) that contains 6-9 wt% carbonate in apatitic structure is the composition of human bone. Unfortunately, CO3Ap cannot be sintered due to the presence of CO3. CO3Ap block was found to be fabricated based on a compositional transformation though dissolution-precipitation reaction using a precursor such as calcite block. CO3Ap block thus fabricated up-regulate the differentiation of osteoblastic cells and resorbed by the osteoclasts. As results of these response to cells, CO3Ap block demonstrate much better osteoconductivity than hydroxyapatite [HAp: Ca10(PO4)6(OH)2)] which is currently used artificial bone substitute. Also, CO3Ap block was found to be replace to new bone similar to autograft even though HAp would not replace to bone. Clinical trial of CO3Ap is now in progress, and CO3Ap will be available for its clinical use next year.

AB - Carbonate apatite (CO3Ap) that contains 6-9 wt% carbonate in apatitic structure is the composition of human bone. Unfortunately, CO3Ap cannot be sintered due to the presence of CO3. CO3Ap block was found to be fabricated based on a compositional transformation though dissolution-precipitation reaction using a precursor such as calcite block. CO3Ap block thus fabricated up-regulate the differentiation of osteoblastic cells and resorbed by the osteoclasts. As results of these response to cells, CO3Ap block demonstrate much better osteoconductivity than hydroxyapatite [HAp: Ca10(PO4)6(OH)2)] which is currently used artificial bone substitute. Also, CO3Ap block was found to be replace to new bone similar to autograft even though HAp would not replace to bone. Clinical trial of CO3Ap is now in progress, and CO3Ap will be available for its clinical use next year.

UR - http://www.scopus.com/inward/record.url?scp=85018523920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018523920&partnerID=8YFLogxK

U2 - 10.2465/gkk.161217

DO - 10.2465/gkk.161217

M3 - Article

AN - SCOPUS:85018523920

VL - 46

SP - 42

EP - 46

JO - Japanese Magazine of Mineralogical and Petrological Sciences

JF - Japanese Magazine of Mineralogical and Petrological Sciences

SN - 1349-7979

IS - 1

ER -