Development of CD8α-positive dendritic cells from a common myeloid progenitor

D. Traver, Koichi Akashi, M. Manz, M. Merad, Toshihiro Miyamoto, E. G. Engleman, I. L. Weissman

Research output: Contribution to journalArticle

315 Citations (Scopus)

Abstract

Dendritic cells (DCs) are critical in both initiating adaptive immune responses and maintaining tolerance to self antigens. These apparently contradictory roles have been suggested to depend on different subsets of DCs that arise from either myeloid or lymphoid hematopoietic origins, respectively. Although DC expression of CD8α is attributed to a lymphoid origin, here we show that both CD8α+ and CD8α- DCs can arise from clonogenic common myeloid progenitors in both thymus and spleen. Thus, expression of CD8α is not indicative of a lymphoid origin, and phenotypic and functional differences among DC subsets are likely to reflect maturation status rather than ontogeny.

Original languageEnglish
Pages (from-to)2152-2154
Number of pages3
JournalScience
Volume290
Issue number5499
DOIs
Publication statusPublished - Dec 15 2000
Externally publishedYes

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Myeloid Progenitor Cells
Dendritic Cells
Autoantigens
Adaptive Immunity
Thymus Gland
Spleen

All Science Journal Classification (ASJC) codes

  • General

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Development of CD8α-positive dendritic cells from a common myeloid progenitor. / Traver, D.; Akashi, Koichi; Manz, M.; Merad, M.; Miyamoto, Toshihiro; Engleman, E. G.; Weissman, I. L.

In: Science, Vol. 290, No. 5499, 15.12.2000, p. 2152-2154.

Research output: Contribution to journalArticle

Traver, D, Akashi, K, Manz, M, Merad, M, Miyamoto, T, Engleman, EG & Weissman, IL 2000, 'Development of CD8α-positive dendritic cells from a common myeloid progenitor', Science, vol. 290, no. 5499, pp. 2152-2154. https://doi.org/10.1126/science.290.5499.2152
Traver, D. ; Akashi, Koichi ; Manz, M. ; Merad, M. ; Miyamoto, Toshihiro ; Engleman, E. G. ; Weissman, I. L. / Development of CD8α-positive dendritic cells from a common myeloid progenitor. In: Science. 2000 ; Vol. 290, No. 5499. pp. 2152-2154.
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