TY - GEN
T1 - Development of Compact Readout Device for Neural Observation System using Fluorescence Imaging and Fast-scan Cyclic Voltammetry
AU - Siwadamrongpong, Ronnakorn
AU - Sato, Nicha
AU - Sugie, Kenji
AU - Ohta, Yasumi
AU - Haruta, Makito
AU - Takehara, Hironari
AU - Tashiro, Hiroyuki
AU - Sasagawa, Kiyotaka
AU - Ohta, Jun
N1 - Funding Information:
*This work was supported by JSPS KAKENHI (Grant Numbers JP18H03780, and 21H03809); and VLSI Design and Education Centre (VDEC), University of Tokyo, with the collaboration of Cadence Corporation and Mentor Graphics Corporation.
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - A readout device for a dual-functional neural observation system is presented. The authors separately developed the reading operation of an implantable CMOS image sensor and a setup for fast-scan cyclic voltammetry and implemented them together in a microcontroller-based device. The developed imaging readout device with a size of 3.0× 5.5{cm}^{2 can reach the highest reading rate of 160 fps with a 120× 268 pixel image sensor. The voltammetry function was verified through an experiment using commercial carbon fiber electrodes in phosphate-buffered saline. When the imaging is sequentially operated with 400 V/s-scan rate voltammetry from -0.4 to 1.3 V, the system can operate at up to 60 fps. With this system, calcium imaging and dopamine recording in a freely behaving mouse can be achieved together in a simpler manner. This study aims to be the basis for the development of an implantable multi-functional sensor.
AB - A readout device for a dual-functional neural observation system is presented. The authors separately developed the reading operation of an implantable CMOS image sensor and a setup for fast-scan cyclic voltammetry and implemented them together in a microcontroller-based device. The developed imaging readout device with a size of 3.0× 5.5{cm}^{2 can reach the highest reading rate of 160 fps with a 120× 268 pixel image sensor. The voltammetry function was verified through an experiment using commercial carbon fiber electrodes in phosphate-buffered saline. When the imaging is sequentially operated with 400 V/s-scan rate voltammetry from -0.4 to 1.3 V, the system can operate at up to 60 fps. With this system, calcium imaging and dopamine recording in a freely behaving mouse can be achieved together in a simpler manner. This study aims to be the basis for the development of an implantable multi-functional sensor.
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U2 - 10.1109/EMBC48229.2022.9871016
DO - 10.1109/EMBC48229.2022.9871016
M3 - Conference contribution
C2 - 36085844
AN - SCOPUS:85138126697
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 4864
EP - 4867
BT - 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
Y2 - 11 July 2022 through 15 July 2022
ER -