Development of drug carrier responding to Matrix Metalloproteinase II

Kentaro Nishi; Takeshi Mori; Takuro Niidome; Yoshiki Katayama

Development of drug carrier responding to Matrix Metalloproteinase II

Kentaro Nishi, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Materials Science and Engineering, School of Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

Matrix Metalloproteinase II (MMP II) plays a key role when cancer cells perform invasion and metastasis by degrading a collagen. Moreover, the expression of this proteinase is enhanced in bone destruction in rheumatoid arthritis. We create a novel drug delivery system that can respond to MMP II. In our DDS, the micelle which is formed from amphiphilic copolymers is used as a drug carrier. The copolymer is composed of hydrophobic polymer main chain and hydrophilic polyethylene glycol side chain which is linked to the main chain with substrate of MMP II. The micelle will be coagulated by digestion of the substrate by MMP II that is enhanced in cancer invasion and rheumatoid and will release the incorporated drug. To realize the DDS, we synthesized the copolymers and studied their physicochemical properties.

Original language	English
Number of pages	1
Publication status	Published - Oct 19 2006
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006

Other

Other	55th SPSJ Annual Meeting
Country	Japan
City	Nagoya
Period	5/24/06 → 5/26/06

All Science Journal Classification (ASJC) codes

Engineering(all)

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abstract = "Matrix Metalloproteinase II (MMP II) plays a key role when cancer cells perform invasion and metastasis by degrading a collagen. Moreover, the expression of this proteinase is enhanced in bone destruction in rheumatoid arthritis. We create a novel drug delivery system that can respond to MMP II. In our DDS, the micelle which is formed from amphiphilic copolymers is used as a drug carrier. The copolymer is composed of hydrophobic polymer main chain and hydrophilic polyethylene glycol side chain which is linked to the main chain with substrate of MMP II. The micelle will be coagulated by digestion of the substrate by MMP II that is enhanced in cancer invasion and rheumatoid and will release the incorporated drug. To realize the DDS, we synthesized the copolymers and studied their physicochemical properties.",

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AU - Nishi, Kentaro

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Katayama, Yoshiki

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N2 - Matrix Metalloproteinase II (MMP II) plays a key role when cancer cells perform invasion and metastasis by degrading a collagen. Moreover, the expression of this proteinase is enhanced in bone destruction in rheumatoid arthritis. We create a novel drug delivery system that can respond to MMP II. In our DDS, the micelle which is formed from amphiphilic copolymers is used as a drug carrier. The copolymer is composed of hydrophobic polymer main chain and hydrophilic polyethylene glycol side chain which is linked to the main chain with substrate of MMP II. The micelle will be coagulated by digestion of the substrate by MMP II that is enhanced in cancer invasion and rheumatoid and will release the incorporated drug. To realize the DDS, we synthesized the copolymers and studied their physicochemical properties.

AB - Matrix Metalloproteinase II (MMP II) plays a key role when cancer cells perform invasion and metastasis by degrading a collagen. Moreover, the expression of this proteinase is enhanced in bone destruction in rheumatoid arthritis. We create a novel drug delivery system that can respond to MMP II. In our DDS, the micelle which is formed from amphiphilic copolymers is used as a drug carrier. The copolymer is composed of hydrophobic polymer main chain and hydrophilic polyethylene glycol side chain which is linked to the main chain with substrate of MMP II. The micelle will be coagulated by digestion of the substrate by MMP II that is enhanced in cancer invasion and rheumatoid and will release the incorporated drug. To realize the DDS, we synthesized the copolymers and studied their physicochemical properties.

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