Development of drug carriers for therapy of arterioscleosis

Kenjiro Ikuta, Takeshi Mori, Takuro Niidome, Hiroaki Shimokawa, Yoshiki Katayama

Research output: Contribution to conferencePaper

Abstract

The vascular endothelium dysfunction often leads to a cardiovascular disease such as arteriosclerosis. Therefore, detection and evaluation of vascular endothelium disorder in early stage would be very important for the effective diagnosis and therapy. We found that the structural analogues of Evans Blue adsorb to a vascular endothelium denuded region. Thus, we synthesized a polymeric drug carrier which consisted of amphipathic polymer and sensing unit (Evans Blue analogue) and evaluated the characteristics of the polymeric carriers. And then a extracted porcine aorta which was removed endothelial cell in left half area was treated with the micelle solution to evaluate a targeting ability of the micelle.

Original languageEnglish
Pages5459-5460
Number of pages2
Publication statusPublished - Dec 1 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

Fingerprint

Micelles
Endothelial cells
Polymers

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Ikuta, K., Mori, T., Niidome, T., Shimokawa, H., & Katayama, Y. (2006). Development of drug carriers for therapy of arterioscleosis. 5459-5460. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.

Development of drug carriers for therapy of arterioscleosis. / Ikuta, Kenjiro; Mori, Takeshi; Niidome, Takuro; Shimokawa, Hiroaki; Katayama, Yoshiki.

2006. 5459-5460 Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.

Research output: Contribution to conferencePaper

Ikuta, K, Mori, T, Niidome, T, Shimokawa, H & Katayama, Y 2006, 'Development of drug carriers for therapy of arterioscleosis' Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 9/20/06 - 9/22/06, pp. 5459-5460.
Ikuta K, Mori T, Niidome T, Shimokawa H, Katayama Y. Development of drug carriers for therapy of arterioscleosis. 2006. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.
Ikuta, Kenjiro ; Mori, Takeshi ; Niidome, Takuro ; Shimokawa, Hiroaki ; Katayama, Yoshiki. / Development of drug carriers for therapy of arterioscleosis. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.2 p.
@conference{b9255ea7f088457783262f9e4b1eb0ff,
title = "Development of drug carriers for therapy of arterioscleosis",
abstract = "The vascular endothelium dysfunction often leads to a cardiovascular disease such as arteriosclerosis. Therefore, detection and evaluation of vascular endothelium disorder in early stage would be very important for the effective diagnosis and therapy. We found that the structural analogues of Evans Blue adsorb to a vascular endothelium denuded region. Thus, we synthesized a polymeric drug carrier which consisted of amphipathic polymer and sensing unit (Evans Blue analogue) and evaluated the characteristics of the polymeric carriers. And then a extracted porcine aorta which was removed endothelial cell in left half area was treated with the micelle solution to evaluate a targeting ability of the micelle.",
author = "Kenjiro Ikuta and Takeshi Mori and Takuro Niidome and Hiroaki Shimokawa and Yoshiki Katayama",
year = "2006",
month = "12",
day = "1",
language = "English",
pages = "5459--5460",
note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - CONF

T1 - Development of drug carriers for therapy of arterioscleosis

AU - Ikuta, Kenjiro

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Shimokawa, Hiroaki

AU - Katayama, Yoshiki

PY - 2006/12/1

Y1 - 2006/12/1

N2 - The vascular endothelium dysfunction often leads to a cardiovascular disease such as arteriosclerosis. Therefore, detection and evaluation of vascular endothelium disorder in early stage would be very important for the effective diagnosis and therapy. We found that the structural analogues of Evans Blue adsorb to a vascular endothelium denuded region. Thus, we synthesized a polymeric drug carrier which consisted of amphipathic polymer and sensing unit (Evans Blue analogue) and evaluated the characteristics of the polymeric carriers. And then a extracted porcine aorta which was removed endothelial cell in left half area was treated with the micelle solution to evaluate a targeting ability of the micelle.

AB - The vascular endothelium dysfunction often leads to a cardiovascular disease such as arteriosclerosis. Therefore, detection and evaluation of vascular endothelium disorder in early stage would be very important for the effective diagnosis and therapy. We found that the structural analogues of Evans Blue adsorb to a vascular endothelium denuded region. Thus, we synthesized a polymeric drug carrier which consisted of amphipathic polymer and sensing unit (Evans Blue analogue) and evaluated the characteristics of the polymeric carriers. And then a extracted porcine aorta which was removed endothelial cell in left half area was treated with the micelle solution to evaluate a targeting ability of the micelle.

UR - http://www.scopus.com/inward/record.url?scp=33846165112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846165112&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846165112

SP - 5459

EP - 5460

ER -