Development of electrospray ionization interface-integrated microchip for mass spectrometric detection in electrophoresis

M. Oketani, T. Kawai, T. Naito, K. Sueyoshi, T. Kubo, F. Kitagawa, K. Otsuka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of an electrospray ionization (ESI) interface-integrated microchip for simple and highly sensitive analysis by microchip electrophoresis (MCE) directly coupled to ESI-mass spectrometry (MS) is reported. The developed device provided a good combination of MCE-ESI-MS with on-line sample concentration based on the concept of large-volume sample stacking with an electroosmotic flow pump (LVSEP). Fluorescence imaging showed the applicability of the developed device to both ESI-MS detection and on-line sample concentration by LVSEP.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages551-553
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - 2013
Externally publishedYes
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: Oct 27 2013Oct 31 2013

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume1

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Country/TerritoryGermany
CityFreiburg
Period10/27/1310/31/13

All Science Journal Classification (ASJC) codes

  • Bioengineering

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