Development of layered porous poly(l-lactide) for bone regeneration

Joo Eon Park, Mitsugu Todo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A study was conducted to demonstrate the development of layered porous poly(L-lactide) (PLLA) for bone regeneration. Porous structure of PLLA was fabricated by the solid-liquid phase separation and freeze-drying methods. PLLA pellets were dissolved in 1,4-dioxane to make 3 and 7 wt% solutions in the first process and the solutions were filled into a test tube in which a PLLA film with a thickness of 250 μm was inserted. The PLLA dioxane solutions in test tubes were cooled from the bottom surfaces at a constant rate by using liquid nitrogen to induce solid-liquid phase separation. The phase-separated samples were dried under vacuum at -5 °C for about 1 week to remove the solvent completely. Cylindrical samples were obtained and trimmed to be a cylinder with 8.5 mm diameter and 11 mm length. The diameter and length of each of the samples were measured at three different positions and averaged values were used to estimate the volume of the cylinder.

Original languageEnglish
Pages (from-to)3966-3968
Number of pages3
JournalJournal of Materials Science
Volume45
Issue number14
DOIs
Publication statusPublished - Jul 1 2010

Fingerprint

Bone
Phase separation
Liquids
Liquid nitrogen
Drying
Vacuum
dilactide
poly(lactide)
1,4-dioxane

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Development of layered porous poly(l-lactide) for bone regeneration. / Park, Joo Eon; Todo, Mitsugu.

In: Journal of Materials Science, Vol. 45, No. 14, 01.07.2010, p. 3966-3968.

Research output: Contribution to journalArticle

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