Development of new 1,3-diazaphenoxazine derivatives (thiog-grasp) to covalently capture 8-thioguanosine

Yasufumi Fuchi, Hideto Obayashi, Shigeki Sasaki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8-thioguanosine via multiple hydrogen-bonded complexes. The thioG-grasp derivative with a propyl linker reacted efficiently with 8-thioguanosine to form the corresponding adduct.

Original languageEnglish
Pages (from-to)1078-1087
Number of pages10
JournalMolecules
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Hand Strength
Derivatives
clamps
adducts
attack
chlorine
atoms
sulfur
Atoms
Signal transduction
Chlorine
hydrogen
Sulfur
Hydrogen
Signal Transduction
8-thioguanosine
1,3-diazaphenoxazine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Development of new 1,3-diazaphenoxazine derivatives (thiog-grasp) to covalently capture 8-thioguanosine. / Fuchi, Yasufumi; Obayashi, Hideto; Sasaki, Shigeki.

In: Molecules, Vol. 20, No. 1, 01.01.2015, p. 1078-1087.

Research output: Contribution to journalArticle

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