Development of new asymmetric two-center catalysts in phase-transfer reactions

Tomoyuki Shibuguchi, Yuhei Fukuta, Yoko Akachi, Akihiro Sekine, Takashi Ohshima, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

157 Citations (Scopus)

Abstract

A new asymmetric two-center phase-transfer catalyst was designed and a catalyst library containing more than 40 new two-center catalysts was constructed. The catalysts were applied in phase-transfer alkylations and Michael additions to afford the corresponding products in up to 93% ee and 82% ee, respectively.

Original languageEnglish
Pages (from-to)9539-9543
Number of pages5
JournalTetrahedron Letters
Volume43
Issue number52
DOIs
Publication statusPublished - Dec 23 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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