MRI造影剤の影響を回避した新しい 血清カルシウム測定試薬の開発

Translated title of the contribution: Development of new measurement reagent for serum calcium that avoids influences of gadolinium contrast agent for MRI

Eisaku Hokazono, Tomota Nakano, Yuji Oguchi, Osawa Susumu

Research output: Contribution to journalArticle

Abstract

We previously reported a serum calcium measurement method using Chlorophosphonazo- III (CPZ-III). In this method, the reagent stability is higher than in conventional methods to react samples in an acid medium. High specificity to calcium is also achieved due to the addition of a surfac- tant to the reagent. However, gadolinium, which is used as a contrast agent for magnetic resonance imaging (MRI), causes a positive error in the measurement. Therefore, we have improved our previous method, and developed a new measurement reagent that is not affected by gadolinium. As a result, it was confirmed not to be unaffected by gadolinium to 2.0 mmol/L. Finally, even if our new method is employed just after using a contrast agent, the serum calcium tests should be unaffected. We expect this method to be used as a routine and emergency test in clinical laboratories because it is stable, accurate, and does not contain any heavy metals, dangerous materials, or mutagenic substances.
Translated title of the contributionDevelopment of new measurement reagent for serum calcium that avoids influences of gadolinium contrast agent for MRI
Original languageJapanese
Pages (from-to)191-197
JournalJournal of Analytical Bio-Science
Volume33
Issue number2
Publication statusPublished - Mar 2010

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