Development of novel functional molecules targeting DNA and RNA

Research output: Contribution to journalReview article

Abstract

Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have attracted increasing attention as innovative medicines that interfere with and/or modify gene expression systems. We have developed new functional oligonucleotides that can target DNA and RNA with high efficiency and selectivity. This review summarizes our achievements, including (1) the formation of non-natural triplex DNA for sequence-specific inhibition of transcription; (2) artificial receptor molecules for 8-oxidized-guanosine nucleosides; and (3) reactive oligonucleotides with a cross-linking agent or a functionality-transfer nucleoside for RNA pinpoint modification.

Original languageEnglish
Pages (from-to)505-518
Number of pages14
JournalChemical and Pharmaceutical Bulletin
Volume67
Issue number6
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Nucleosides
Oligonucleotides
Artificial Receptors
RNA
Molecules
Guanosine
DNA
Transcription
Transfer RNA
Gene expression
Nucleic Acids
Small Interfering RNA
Medicine
Efficiency
Gene Expression
Therapeutics
triplex DNA
Inhibition (Psychology)

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Development of novel functional molecules targeting DNA and RNA. / Sasaki, Shigeki.

In: Chemical and Pharmaceutical Bulletin, Vol. 67, No. 6, 01.01.2019, p. 505-518.

Research output: Contribution to journalReview article

@article{bc1759ff08b34dd2bb7da208e24ca97c,
title = "Development of novel functional molecules targeting DNA and RNA",
abstract = "Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have attracted increasing attention as innovative medicines that interfere with and/or modify gene expression systems. We have developed new functional oligonucleotides that can target DNA and RNA with high efficiency and selectivity. This review summarizes our achievements, including (1) the formation of non-natural triplex DNA for sequence-specific inhibition of transcription; (2) artificial receptor molecules for 8-oxidized-guanosine nucleosides; and (3) reactive oligonucleotides with a cross-linking agent or a functionality-transfer nucleoside for RNA pinpoint modification.",
author = "Shigeki Sasaki",
year = "2019",
month = "1",
day = "1",
doi = "10.1248/cpb.c19-00169",
language = "English",
volume = "67",
pages = "505--518",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "The Pharmaceutical Society of Japan",
number = "6",

}

TY - JOUR

T1 - Development of novel functional molecules targeting DNA and RNA

AU - Sasaki, Shigeki

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have attracted increasing attention as innovative medicines that interfere with and/or modify gene expression systems. We have developed new functional oligonucleotides that can target DNA and RNA with high efficiency and selectivity. This review summarizes our achievements, including (1) the formation of non-natural triplex DNA for sequence-specific inhibition of transcription; (2) artificial receptor molecules for 8-oxidized-guanosine nucleosides; and (3) reactive oligonucleotides with a cross-linking agent or a functionality-transfer nucleoside for RNA pinpoint modification.

AB - Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have attracted increasing attention as innovative medicines that interfere with and/or modify gene expression systems. We have developed new functional oligonucleotides that can target DNA and RNA with high efficiency and selectivity. This review summarizes our achievements, including (1) the formation of non-natural triplex DNA for sequence-specific inhibition of transcription; (2) artificial receptor molecules for 8-oxidized-guanosine nucleosides; and (3) reactive oligonucleotides with a cross-linking agent or a functionality-transfer nucleoside for RNA pinpoint modification.

UR - http://www.scopus.com/inward/record.url?scp=85067099036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067099036&partnerID=8YFLogxK

U2 - 10.1248/cpb.c19-00169

DO - 10.1248/cpb.c19-00169

M3 - Review article

VL - 67

SP - 505

EP - 518

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 6

ER -