Development of novel telomerase inhibitors based on a bisindole unit

Shigeki Sasaki, Takeru Ehara, Ikuhiro Sakata, Yasuhiro Fujino, Naozumi Harada, Junko Kimura, Hideo Nakamura, Minoru Maeda

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Telomerase is the enzyme that elongates telomere repeat at the ends of a chromosome. As high telomerase activity is observed in most cancer cells, inhibitors of human telomerase have been expected as new chemotherapeutic agents for cancer. We describe here the discovery of novel inhibitors with IC50 values in the submicromolar range. The structure of the novel inhibitors will be useful as a scaffold for construction of the library in the search for telomerase inhibitors.

Original languageEnglish
Pages (from-to)583-585
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number4
DOIs
Publication statusPublished - Feb 26 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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