Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice

Akio Takahashi, Kazumasa Ogasawara, Naoto Matsuki, Koh Fujinaga, Takaaki Nakaya, Kazuyoshi Ikuta, Wattana Auwanit, Mitsuo Honda, Yoshinori Fukui, Takehiko Sasazuki, Kazuya Iwabuchi, Kazunori Onoé

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Peptide vaccines against HIV-1 were prepared according to the cassette theory that we had proposed previously. An amino acid sequence of B subtype consensus of the HIV-1 V3 region was introduced into the MHC binding component with a supermotif for various MHC class II. The peptide vaccines induced T-cell responses in the DQ6 mice in which only DQ6 molecules were expressed as MHC class II. By contrast, an original V3 peptide including the consensus sequence was non-immunogenic in the DQ6 mice. Antibodies obtained from the DQ6 mice immunized with the peptide vaccines neutralized laboratory B subtype strains of HIV-1 in vitro. It may be anticipated that these peptide vaccines protect infection of HIV-1 in DQ6 positive individuals.

Original languageEnglish
Pages (from-to)1537-1543
Number of pages7
JournalVaccine
Volume16
Issue number16
DOIs
Publication statusPublished - Oct 1 1998

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice'. Together they form a unique fingerprint.

  • Cite this

    Takahashi, A., Ogasawara, K., Matsuki, N., Fujinaga, K., Nakaya, T., Ikuta, K., Auwanit, W., Honda, M., Fukui, Y., Sasazuki, T., Iwabuchi, K., & Onoé, K. (1998). Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice. Vaccine, 16(16), 1537-1543. https://doi.org/10.1016/S0264-410X(98)00042-5