Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice

Akio Takahashi, Kazumasa Ogasawara, Naoto Matsuki, Koh Fujinaga, Takaaki Nakaya, Kazuyoshi Ikuta, Wattana Auwanit, Mitsuo Honda, Yoshinori Fukui, Takehiko Sasazuki, Kazuya Iwabuchi, Kazunori Onoé

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Peptide vaccines against HIV-1 were prepared according to the cassette theory that we had proposed previously. An amino acid sequence of B subtype consensus of the HIV-1 V3 region was introduced into the MHC binding component with a supermotif for various MHC class II. The peptide vaccines induced T-cell responses in the DQ6 mice in which only DQ6 molecules were expressed as MHC class II. By contrast, an original V3 peptide including the consensus sequence was non-immunogenic in the DQ6 mice. Antibodies obtained from the DQ6 mice immunized with the peptide vaccines neutralized laboratory B subtype strains of HIV-1 in vitro. It may be anticipated that these peptide vaccines protect infection of HIV-1 in DQ6 positive individuals.

Original languageEnglish
Pages (from-to)1537-1543
Number of pages7
JournalVaccine
Volume16
Issue number16
DOIs
Publication statusPublished - Oct 1 1998

Fingerprint

Subunit Vaccines
subunit vaccines
Human immunodeficiency virus 1
Neutralizing Antibodies
neutralizing antibodies
HIV-1
Viruses
viruses
mice
consensus sequence
Consensus Sequence
Amino Acid Sequence
amino acid sequences
T-lymphocytes
peptides
T-Lymphocytes
Peptides
antibodies
HLA-DQ6 antigen
Antibodies

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Takahashi, A., Ogasawara, K., Matsuki, N., Fujinaga, K., Nakaya, T., Ikuta, K., ... Onoé, K. (1998). Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice. Vaccine, 16(16), 1537-1543. https://doi.org/10.1016/S0264-410X(98)00042-5

Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice. / Takahashi, Akio; Ogasawara, Kazumasa; Matsuki, Naoto; Fujinaga, Koh; Nakaya, Takaaki; Ikuta, Kazuyoshi; Auwanit, Wattana; Honda, Mitsuo; Fukui, Yoshinori; Sasazuki, Takehiko; Iwabuchi, Kazuya; Onoé, Kazunori.

In: Vaccine, Vol. 16, No. 16, 01.10.1998, p. 1537-1543.

Research output: Contribution to journalArticle

Takahashi, A, Ogasawara, K, Matsuki, N, Fujinaga, K, Nakaya, T, Ikuta, K, Auwanit, W, Honda, M, Fukui, Y, Sasazuki, T, Iwabuchi, K & Onoé, K 1998, 'Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice', Vaccine, vol. 16, no. 16, pp. 1537-1543. https://doi.org/10.1016/S0264-410X(98)00042-5
Takahashi, Akio ; Ogasawara, Kazumasa ; Matsuki, Naoto ; Fujinaga, Koh ; Nakaya, Takaaki ; Ikuta, Kazuyoshi ; Auwanit, Wattana ; Honda, Mitsuo ; Fukui, Yoshinori ; Sasazuki, Takehiko ; Iwabuchi, Kazuya ; Onoé, Kazunori. / Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice. In: Vaccine. 1998 ; Vol. 16, No. 16. pp. 1537-1543.
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