Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction

Kenjiro Ikuta, Takeshi Mori, Tatsurhiro Yamamoto, Takuro Niidome, Hiroaki Shimokawa, Yoshiki Katayama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The vascular endothelium plays an important role in regulating vascular homeostasis. Damage to the endothelium can lead to cardiovascular diseases such as arteriosclerosis. Therefore, early-stage detection and evaluation of vascular endothelium dysfunction would be very important for effective diagnosis and therapy. We synthesized a polymeric drug carrier bearing an Evans blue analogue as a probing unit for endothelium injury. The polymeric carrier spontaneously formed stable nanoparticles with micelle-like structure in aqueous media and could encapsulate hydrophobic doxorubicin (DOX). The encapsulated DOX showed a sustainable release profile over a period of 10-60 h depending on the loaded DOX concentration. The polymeric carrier specifically adsorbed against the endothelium-injured site in extracted porcine aorta. These properties of the polymeric drug carrier will be suitable for specific drug delivery to endothelium dysfunctional region.

Original languageEnglish
Pages (from-to)2811-2818
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number6
DOIs
Publication statusPublished - Mar 15 2008

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Drug Delivery Systems
Doxorubicin
Endothelium
Blood Vessels
Drug Carriers
Vascular Endothelium
Bearings (structural)
Evans Blue
Micelles
Drug delivery
Arteriosclerosis
Nanoparticles
Aorta
Homeostasis
Cardiovascular Diseases
Swine
Wounds and Injuries
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction. / Ikuta, Kenjiro; Mori, Takeshi; Yamamoto, Tatsurhiro; Niidome, Takuro; Shimokawa, Hiroaki; Katayama, Yoshiki.

In: Bioorganic and Medicinal Chemistry, Vol. 16, No. 6, 15.03.2008, p. 2811-2818.

Research output: Contribution to journalArticle

Ikuta, Kenjiro ; Mori, Takeshi ; Yamamoto, Tatsurhiro ; Niidome, Takuro ; Shimokawa, Hiroaki ; Katayama, Yoshiki. / Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction. In: Bioorganic and Medicinal Chemistry. 2008 ; Vol. 16, No. 6. pp. 2811-2818.
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