Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis

Ravindra Pal Singh, Jiro Nakayama

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Enterococcus spp. can cause illnesses such as bacteremia, endocarditis, urinary tract infections, posttreatment endophthalmitis, and endodontic infections (Murray 2000; Marothi et al. 2005). Medical treatment of these infectious diseases depends largely on bactericidal or bacteriostatic antibiotics. However, frequent use of such antibiotics has led to the development of drug-resistant bacterial strains, which are difficult to treat (Marothi et al. 2005; Murray 2000). As a result, the blockage of bacterial quorum-sensing (QS) systems has attracted attention owing to its potential to attenuate bacterial virulence without inducing bactericidal pressures that lead to drug resistance. This approach, called quorum quenching (QQ), can be undertaken partially or completely independently of antibiotic treatment. Among several QQ strategies, the use of QS inhibitors (QSIs), which are small molecules that have no adverse effects on bacteria, offers advantages in terms of drug delivery and decreased damage to commensal microbiota.

Original languageEnglish
Title of host publicationQuorum Sensing vs Quorum Quenching: A Battle with no end in Sight
PublisherSpringer India
Pages319-326
Number of pages8
ISBN (Electronic)9788132219828
ISBN (Print)9788132219811
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Quorum Sensing
quorum sensing
Enterococcus faecalis
antibiotics
Anti-Bacterial Agents
Quenching
urinary tract diseases
drugs
endocarditis
bacteremia
medical treatment
drug resistance
Enterococcus
Drug delivery
Pharmaceutical Preparations
infectious diseases
Endophthalmitis
Endodontics
Microbiota
Bacteria

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Singh, R. P., & Nakayama, J. (2015). Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis. In Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight (pp. 319-326). Springer India. https://doi.org/10.1007/978-81-322-1982-8__25

Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis. / Singh, Ravindra Pal; Nakayama, Jiro.

Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight. Springer India, 2015. p. 319-326.

Research output: Chapter in Book/Report/Conference proceedingChapter

Singh, RP & Nakayama, J 2015, Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis. in Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight. Springer India, pp. 319-326. https://doi.org/10.1007/978-81-322-1982-8__25
Singh RP, Nakayama J. Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis. In Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight. Springer India. 2015. p. 319-326 https://doi.org/10.1007/978-81-322-1982-8__25
Singh, Ravindra Pal ; Nakayama, Jiro. / Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis. Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight. Springer India, 2015. pp. 319-326
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