Development of redox metabolic imaging using endogenous molecules

Fuminori Hyodo, Shinji Ito, Hinako Eto, Tomoko Nakaji, Keiji Yasukawa, Ryoma Kobayashi, Hideo Utsumi

    Research output: Contribution to journalReview article

    1 Citation (Scopus)

    Abstract

    Redox metabolism plays a central role in maintaining homeostasis in living organisms. The electron transfer system in mitochondria produces ATP via endogenous redox molecules such as flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), and coenzyme Q 10 (CoQ 10 ), which have flavin or quinone moieties. One-electron transfer reactions convert FMN, FAD, and CoQ 10 to the free radical intermediates FMNH and FADH, and CoQ 10 H, respectively. Dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) allows us to visualize free radicals in vitro and in vivo. We present a spectroscopic imaging technology with DNP-MRI, which enables the imaging of multiple free radical intermediates such as FADH and CoQH. DNP-MRI can also identify various endogenous free radical intermediates derived from redox transformations.

    Original languageEnglish
    Pages (from-to)1107-1114
    Number of pages8
    JournalYakugaku Zasshi
    Volume136
    Issue number8
    DOIs
    Publication statusPublished - Jan 1 2016

    Fingerprint

    Oxidation-Reduction
    Free Radicals
    Ubiquinone
    Flavin Mononucleotide
    Flavin-Adenine Dinucleotide
    Magnetic Resonance Spectroscopy
    Magnetic Resonance Imaging
    Electrons
    Mitochondria
    Homeostasis
    Adenosine Triphosphate
    Technology

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Pharmaceutical Science

    Cite this

    Hyodo, F., Ito, S., Eto, H., Nakaji, T., Yasukawa, K., Kobayashi, R., & Utsumi, H. (2016). Development of redox metabolic imaging using endogenous molecules. Yakugaku Zasshi, 136(8), 1107-1114. https://doi.org/10.1248/yakushi.15-00234-6

    Development of redox metabolic imaging using endogenous molecules. / Hyodo, Fuminori; Ito, Shinji; Eto, Hinako; Nakaji, Tomoko; Yasukawa, Keiji; Kobayashi, Ryoma; Utsumi, Hideo.

    In: Yakugaku Zasshi, Vol. 136, No. 8, 01.01.2016, p. 1107-1114.

    Research output: Contribution to journalReview article

    Hyodo, F, Ito, S, Eto, H, Nakaji, T, Yasukawa, K, Kobayashi, R & Utsumi, H 2016, 'Development of redox metabolic imaging using endogenous molecules', Yakugaku Zasshi, vol. 136, no. 8, pp. 1107-1114. https://doi.org/10.1248/yakushi.15-00234-6
    Hyodo F, Ito S, Eto H, Nakaji T, Yasukawa K, Kobayashi R et al. Development of redox metabolic imaging using endogenous molecules. Yakugaku Zasshi. 2016 Jan 1;136(8):1107-1114. https://doi.org/10.1248/yakushi.15-00234-6
    Hyodo, Fuminori ; Ito, Shinji ; Eto, Hinako ; Nakaji, Tomoko ; Yasukawa, Keiji ; Kobayashi, Ryoma ; Utsumi, Hideo. / Development of redox metabolic imaging using endogenous molecules. In: Yakugaku Zasshi. 2016 ; Vol. 136, No. 8. pp. 1107-1114.
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