Development of redox metabolic imaging using endogenous molecules

Fuminori Hyodo, Shinji Ito, Hinako Eto, Tomoko Nakaji, Keiji Yasukawa, Ryoma Kobayashi, Hideo Utsumi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Redox metabolism plays a central role in maintaining homeostasis in living organisms. The electron transfer system in mitochondria produces ATP via endogenous redox molecules such as flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), and coenzyme Q 10 (CoQ 10 ), which have flavin or quinone moieties. One-electron transfer reactions convert FMN, FAD, and CoQ 10 to the free radical intermediates FMNH and FADH, and CoQ 10 H, respectively. Dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) allows us to visualize free radicals in vitro and in vivo. We present a spectroscopic imaging technology with DNP-MRI, which enables the imaging of multiple free radical intermediates such as FADH and CoQH. DNP-MRI can also identify various endogenous free radical intermediates derived from redox transformations.

Original languageEnglish
Pages (from-to)1107-1114
Number of pages8
JournalYakugaku Zasshi
Volume136
Issue number8
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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    Hyodo, F., Ito, S., Eto, H., Nakaji, T., Yasukawa, K., Kobayashi, R., & Utsumi, H. (2016). Development of redox metabolic imaging using endogenous molecules. Yakugaku Zasshi, 136(8), 1107-1114. https://doi.org/10.1248/yakushi.15-00234-6