Development of the novel drug releasing system triggered by hybridization with target sequence

F. Nagatsugi, Shizuka Nakayama, Shigeki Sasaki

Research output: Contribution to journalArticle

Abstract

We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to the method for the drug releasing system triggered by hybridization with the target sequence.

Original languageEnglish
Pages (from-to)799-803
Number of pages5
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number6-7
DOIs
Publication statusPublished - Jun 1 2007

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics

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