Development of the novel drug releasing system triggered by hybridization with target sequence

F. Nagatsugi, Shizuka Nakayama, Shigeki Sasaki

Research output: Contribution to journalArticle


We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to the method for the drug releasing system triggered by hybridization with the target sequence.

Original languageEnglish
Pages (from-to)799-803
Number of pages5
JournalNucleosides, Nucleotides and Nucleic Acids
Issue number6-7
Publication statusPublished - Jun 1 2007


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics

Cite this