[Development trends for therapeutic antibody].

Eishi Baba, Hitoshi Kusaba, Shuji Nakano

Research output: Contribution to journalReview article

Abstract

Recent developments for therapeutic antibody have provided new options for cancer treatments. Modification of antibody molecules pursuing improvement of binding efficacy for Fcgamma receptors and enabling efficient recycling of antibody have been performed. Novel constructs of antibody possessing multivalent specificity and conjugated agents have also been developed. Based on exploration of new class of target molecules for therapeutic antibody, antibodies enhancing anti-tumor immunity such as anti-CTLA-4 antibody have appeared. These advancements would achieve more effective and safer therapy for various kinds of cancers.

Original languageEnglish
Pages (from-to)2098-2103
Number of pages6
JournalNihon rinsho. Japanese journal of clinical medicine
Volume70
Issue number12
Publication statusPublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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