Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation

Kinichi Nakashima, Stefan Wiese, Makoto Yanagisawa, Hirokazu Arakawa, Naoki Kimura, Tatsuhiro Hisatsune, Kanji Yoshida, Tadamitsu Kishimoto, Michael Sendtner, Tetsuya Taga

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary neurotrophic factor, oncostatin-M, and cardiotrophin-1. We have examined in this study a role of gp130 in the nervous system by analyzing developmental cell death of several neuronal populations and the differentiation of astrocytes in gp130- deficient mice. A significant reduction was observed in the number of sensory neurons in L5 dorsal root ganglia and motoneurons in the facial nucleus, the nucleus ambiguus, and the lumbar spinal cord in gp130 -/- mice on embryonic day 18.5. On the other hand, no significant neuronal loss was detectable on day 14.5, suggesting a physiological role of gp130 in supporting newly generated neurons during the late phase of development when naturally occurring cell death takes place. Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 -/- mice. Our data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytes in vivo.

Original languageEnglish
Pages (from-to)5429-5434
Number of pages6
JournalJournal of Neuroscience
Volume19
Issue number13
Publication statusPublished - Jul 1 1999
Externally publishedYes

Fingerprint

Astrocytes
Motor Neurons
Sensory Receptor Cells
Interleukin-6
Spinal Cord
Cell Death
Oncostatin M
Interleukin-11
Ciliary Neurotrophic Factor
Leukemia Inhibitory Factor
Medulla Oblongata
Spinal Ganglia
Nervous System
Population
Cytokines
Neurons
Brain
cardiotrophin 1
Facial Nucleus

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nakashima, K., Wiese, S., Yanagisawa, M., Arakawa, H., Kimura, N., Hisatsune, T., ... Taga, T. (1999). Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. Journal of Neuroscience, 19(13), 5429-5434.

Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. / Nakashima, Kinichi; Wiese, Stefan; Yanagisawa, Makoto; Arakawa, Hirokazu; Kimura, Naoki; Hisatsune, Tatsuhiro; Yoshida, Kanji; Kishimoto, Tadamitsu; Sendtner, Michael; Taga, Tetsuya.

In: Journal of Neuroscience, Vol. 19, No. 13, 01.07.1999, p. 5429-5434.

Research output: Contribution to journalArticle

Nakashima, K, Wiese, S, Yanagisawa, M, Arakawa, H, Kimura, N, Hisatsune, T, Yoshida, K, Kishimoto, T, Sendtner, M & Taga, T 1999, 'Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation', Journal of Neuroscience, vol. 19, no. 13, pp. 5429-5434.
Nakashima K, Wiese S, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T et al. Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. Journal of Neuroscience. 1999 Jul 1;19(13):5429-5434.
Nakashima, Kinichi ; Wiese, Stefan ; Yanagisawa, Makoto ; Arakawa, Hirokazu ; Kimura, Naoki ; Hisatsune, Tatsuhiro ; Yoshida, Kanji ; Kishimoto, Tadamitsu ; Sendtner, Michael ; Taga, Tetsuya. / Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. In: Journal of Neuroscience. 1999 ; Vol. 19, No. 13. pp. 5429-5434.
@article{25ce4d14cecd4322b85eb2c8045d1b0f,
title = "Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation",
abstract = "gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary neurotrophic factor, oncostatin-M, and cardiotrophin-1. We have examined in this study a role of gp130 in the nervous system by analyzing developmental cell death of several neuronal populations and the differentiation of astrocytes in gp130- deficient mice. A significant reduction was observed in the number of sensory neurons in L5 dorsal root ganglia and motoneurons in the facial nucleus, the nucleus ambiguus, and the lumbar spinal cord in gp130 -/- mice on embryonic day 18.5. On the other hand, no significant neuronal loss was detectable on day 14.5, suggesting a physiological role of gp130 in supporting newly generated neurons during the late phase of development when naturally occurring cell death takes place. Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 -/- mice. Our data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytes in vivo.",
author = "Kinichi Nakashima and Stefan Wiese and Makoto Yanagisawa and Hirokazu Arakawa and Naoki Kimura and Tatsuhiro Hisatsune and Kanji Yoshida and Tadamitsu Kishimoto and Michael Sendtner and Tetsuya Taga",
year = "1999",
month = "7",
day = "1",
language = "English",
volume = "19",
pages = "5429--5434",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "13",

}

TY - JOUR

T1 - Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation

AU - Nakashima, Kinichi

AU - Wiese, Stefan

AU - Yanagisawa, Makoto

AU - Arakawa, Hirokazu

AU - Kimura, Naoki

AU - Hisatsune, Tatsuhiro

AU - Yoshida, Kanji

AU - Kishimoto, Tadamitsu

AU - Sendtner, Michael

AU - Taga, Tetsuya

PY - 1999/7/1

Y1 - 1999/7/1

N2 - gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary neurotrophic factor, oncostatin-M, and cardiotrophin-1. We have examined in this study a role of gp130 in the nervous system by analyzing developmental cell death of several neuronal populations and the differentiation of astrocytes in gp130- deficient mice. A significant reduction was observed in the number of sensory neurons in L5 dorsal root ganglia and motoneurons in the facial nucleus, the nucleus ambiguus, and the lumbar spinal cord in gp130 -/- mice on embryonic day 18.5. On the other hand, no significant neuronal loss was detectable on day 14.5, suggesting a physiological role of gp130 in supporting newly generated neurons during the late phase of development when naturally occurring cell death takes place. Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 -/- mice. Our data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytes in vivo.

AB - gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary neurotrophic factor, oncostatin-M, and cardiotrophin-1. We have examined in this study a role of gp130 in the nervous system by analyzing developmental cell death of several neuronal populations and the differentiation of astrocytes in gp130- deficient mice. A significant reduction was observed in the number of sensory neurons in L5 dorsal root ganglia and motoneurons in the facial nucleus, the nucleus ambiguus, and the lumbar spinal cord in gp130 -/- mice on embryonic day 18.5. On the other hand, no significant neuronal loss was detectable on day 14.5, suggesting a physiological role of gp130 in supporting newly generated neurons during the late phase of development when naturally occurring cell death takes place. Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 -/- mice. Our data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytes in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0033168687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033168687&partnerID=8YFLogxK

M3 - Article

C2 - 10377352

AN - SCOPUS:0033168687

VL - 19

SP - 5429

EP - 5434

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 13

ER -