Developmental toxicity of the common UV filter, benophenone-2, in zebrafish embryos

Henry C.H. Fong, Jeff C.H. Ho, Angela H.Y. Cheung, K. P. Lai, Ka Fai William Tse

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Benozophenone (BP) type UV filters are extensively used in the personal care products to provide protection against the harmful effects of UV radiation. BPs are one of the primary components in the UV filter family, in which benophenone-2 (BP2) is widely used as a UV filter reagent in the sunscreen. Humans used these personal care products directly on skin and the chemicals will be washed away to the water system. BP2 has been identified as one of the endocrine disruptor chemicals, which can inference the synthesis, metabolism, and action of endogenous hormones. Environmentally, it has been found to contaminate water worldwide. In this study, we aimed to unfold the possible developmental toxicology of this chemical. Zebrafish are used as the screening model to perform in situ hybridization staining to investigate the effects of BP2 on segmentation, brain regionalization, and facial formation at four developmental stages (10–12 somite, prim-5, 2 and 5 days post-fertilization). Results showed 40 μM (9.85 mg L−1) or above BP2 exposure in zebrafish embryos for 5 days resulted in lipid accumulation in the yolk sac and facial malformation via affecting the lipid processing and the expression of cranial neural crest cells respectively. To conclude, the study alarmed its potential developmental toxicities at high dosage exposure.

Original languageEnglish
Pages (from-to)413-420
Number of pages8
JournalChemosphere
Volume164
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Zebrafish
Toxicity
embryo
Embryonic Structures
toxicity
filter
Lipids
Endocrine Disruptors
Sunscreening Agents
Somites
Yolk Sac
Water
Neural Crest
Radiation Effects
lipid
Fertilization
Toxicology
Sun hoods
In Situ Hybridization
endocrine disruptor

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Chemistry(all)

Cite this

Developmental toxicity of the common UV filter, benophenone-2, in zebrafish embryos. / Fong, Henry C.H.; Ho, Jeff C.H.; Cheung, Angela H.Y.; Lai, K. P.; Tse, Ka Fai William.

In: Chemosphere, Vol. 164, 01.12.2016, p. 413-420.

Research output: Contribution to journalArticle

Fong, Henry C.H. ; Ho, Jeff C.H. ; Cheung, Angela H.Y. ; Lai, K. P. ; Tse, Ka Fai William. / Developmental toxicity of the common UV filter, benophenone-2, in zebrafish embryos. In: Chemosphere. 2016 ; Vol. 164. pp. 413-420.
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