Diabetes-associated alterations in volatile anesthetic actions on contractile response to norepinephrine in isolated mesenteric resistance arteries

Jun Yoshino, Takashi Akata, Kazuhiro Shirozu, Kaoru Izumi, Sumio Hoka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Clinical concentrations of volatile anesthetics significantly influence contractile response to the sympathetic neurotransmitter norepinephrine although its precise mechanisms remain unclarified. In this study, we investigated its possible alterations in diabetes, as well as its underlying mechanisms. Methods: Isometric force was recorded in small mesenteric arteries from streptozotocin-induced diabetic and age-matched control rats. Results: The concentration-response curve for acetylcholine-induced endothelium-dependent relaxation was shifted to the right in diabetic arteries compared with controls. The concentration-response curve for norepinephrine-induced contraction was shifted to the left and upward by both endothelial denudation and diabetic induction. In the presence of endothelium, isoflurane or sevoflurane enhanced norepinephrine-induced contraction in control arteries but not in diabetic arteries; however, in its absence, both anesthetics identically inhibited norepinephrine-induced contraction in both groups. In control arteries, the isoflurane-or sevoflurane-induced enhancement was not affected by adrenomedullin22-52, calcitonin gene-related peptide8-37, 18β-glycyrrhetinic acid, N-nitro l-arginine, ouabain, Ba, indomethacin, losartan, ketanserin, BQ-123, and BQ-788. Conclusions: In diabetes, vascular responses to acetylcholine, norepinephrine, and volatile anesthetics are altered in mesenteric resistance arteries, presumably reflecting endothelial dysfunction and possibly underlying circulatory instability during administration of either anesthetic. Some endothelial mechanisms that are impaired in diabetes would be involved in the anesthetic-induced enhancement of norepinephrine-induced contraction. However, the vasoregulatory mechanism mediated by adrenomedullin, calcitonin gene-related peptide, myoendothelial gap junction, nitric oxide, endothelium-derived hyperpolarizing factor, cyclooxygenase products, angiotensin II, serotonin, or endothelin-1, all of which have been suggested to be impaired in diabetes, would not be involved in the enhancement.

Original languageEnglish
Pages (from-to)595-606
Number of pages12
JournalAnesthesiology
Volume112
Issue number3
DOIs
Publication statusPublished - Jan 1 2010

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Mesenteric Arteries
Anesthetics
Norepinephrine
Arteries
Isoflurane
Acetylcholine
Endothelium
Glycyrrhetinic Acid
Adrenomedullin
Ketanserin
Losartan
Calcitonin Gene-Related Peptide
Gap Junctions
Calcitonin
Endothelin-1
Ouabain
Prostaglandin-Endoperoxide Synthases
Streptozocin
Indomethacin
Angiotensin II

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Diabetes-associated alterations in volatile anesthetic actions on contractile response to norepinephrine in isolated mesenteric resistance arteries. / Yoshino, Jun; Akata, Takashi; Shirozu, Kazuhiro; Izumi, Kaoru; Hoka, Sumio.

In: Anesthesiology, Vol. 112, No. 3, 01.01.2010, p. 595-606.

Research output: Contribution to journalArticle

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