Diabetes mellitus and dementia

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

Growing epidemiologic evidence has suggested that people with diabetes mellitus are at an increased risk for the development of dementia. However, the results for the subtypes of dementia are inconsistent. This review examines the risk of dementia in people with diabetes mellitus, and discusses the possible mechanism underpinning this association. Diabetes mellitus is associated with a 1.5- to 2.5-fold greater risk of dementia among community-dwelling elderly people. Notably, diabetes mellitus is a significant risk factor for not only vascular dementia, but also Alzheimer's disease. The mechanisms underpinning the association are unclear, but it may be multifactorial in nature, involving factors such as cardiovascular risk factors, glucose toxicity, changes in insulin metabolism and inflammation. The optimal management of these risk factors in early life may be important to prevent late-life dementia. Furthermore, novel therapeutic strategies will be needed to prevent or reduce the development of dementia in people with diabetes mellitus.

Original languageEnglish
JournalCurrent Diabetes Reports
Volume14
Issue number5
DOIs
Publication statusPublished - May 2014

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Dementia
Diabetes Mellitus
Independent Living
Vascular Dementia
Alzheimer Disease
Insulin
Inflammation
Glucose

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Diabetes mellitus and dementia. / Ninomiya, Toshiharu.

In: Current Diabetes Reports, Vol. 14, No. 5, 05.2014.

Research output: Contribution to journalReview article

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