Diagnosis and management of collagenous colitis

Junji Umeno, Takayuki Matsumoto, Shotaro Nakamura, Mitsuo Iida

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Collagenous colitis (CC) is a distinct clinicopathological entity characterized by chronic watery diarrhea and a thickened subepithelial collagen band, and mainly affects middle-aged and elderly women. The etiology of CC is largely unknown ; however, a variety of factors have been implicated including genetic factors, autoimmune diseases, intestinal infections, bile salts and drugs such as proton pump inhibitors, non-steroidal anti-inflammatory analgesics, aspirin, and ticlopidine. Although endoscopy usually reveals only normal or non-specific minimal abnormalities of the colonic mucosa, such as increased capillary growth and multiple longitudinal ulcers called mucosal tears, are occasionally observed. The diagnosis of CC is made based on clinical symptoms and histopathologic features of colonic mucosal biopsies. Improvement may be achieved by cessation of possible causative drugs alone. Antidiarrheal drugs such as loperamide and cholestyramine are recommended as first line treatments, followed by subsequent administration of mesalazine, oral corticosteroids and immunosuppressive drugs in non-respondent cases.

Original languageEnglish
Pages (from-to)1233-1242
Number of pages10
JournalGASTROENTEROLOGICAL ENDOSCOPY
Volume52
Issue number4
Publication statusPublished - May 1 2010

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Collagenous Colitis
Pharmaceutical Preparations
Loperamide
Antidiarrheals
Cholestyramine Resin
Ticlopidine
Mesalamine
Proton Pump Inhibitors
Non-Steroidal Anti-Inflammatory Agents
Immunosuppressive Agents
Bile Acids and Salts
Tears
Endoscopy
Aspirin
Autoimmune Diseases
Ulcer
Oral Administration
Diarrhea
Adrenal Cortex Hormones
Mucous Membrane

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Umeno, J., Matsumoto, T., Nakamura, S., & Iida, M. (2010). Diagnosis and management of collagenous colitis. GASTROENTEROLOGICAL ENDOSCOPY, 52(4), 1233-1242.

Diagnosis and management of collagenous colitis. / Umeno, Junji; Matsumoto, Takayuki; Nakamura, Shotaro; Iida, Mitsuo.

In: GASTROENTEROLOGICAL ENDOSCOPY, Vol. 52, No. 4, 01.05.2010, p. 1233-1242.

Research output: Contribution to journalArticle

Umeno, J, Matsumoto, T, Nakamura, S & Iida, M 2010, 'Diagnosis and management of collagenous colitis', GASTROENTEROLOGICAL ENDOSCOPY, vol. 52, no. 4, pp. 1233-1242.
Umeno J, Matsumoto T, Nakamura S, Iida M. Diagnosis and management of collagenous colitis. GASTROENTEROLOGICAL ENDOSCOPY. 2010 May 1;52(4):1233-1242.
Umeno, Junji ; Matsumoto, Takayuki ; Nakamura, Shotaro ; Iida, Mitsuo. / Diagnosis and management of collagenous colitis. In: GASTROENTEROLOGICAL ENDOSCOPY. 2010 ; Vol. 52, No. 4. pp. 1233-1242.
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