Diagnosis of early colorectal cancer invasion depth by quantitative evaluation of the basal indentation in CT colonography

Mitsutoshi Miyasaka, Daisuke Tsurumaru, Yusuke Nishimuta, Yoshiki Asayama, Satoshi Kawanami, Eiji Oki, Minako Hirahashi, Hiroshi Honda

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the feasibility of diagnosing the invasion depth of early colorectal cancer (CRC) by quantitatively evaluating the basal indentation (BI)—i.e., the intestinal lateral deformity—in CT colonography (CTC). Materials and methods: 34 early CRCs (13 Tis CRCs and 21 T1 CRCs) in 32 patients who underwent a preoperative CTC were retrospectively examined. Two radiologists calculated the depth of the BI on a computed tomographic air-contrast enema (CT enema) image, the depth of the BI due to the geometric function (BI-G) on a cross-sectional multiplanar reconstruction (CS-MPR) image, and the ratio of the BI to the BI-G (i.e., the “BI ratio”) for each lesion. The BI ratios of the Tis and T1 CRCs were compared. Results: The BI ratios were significantly higher in the T1 CRCs than in the Tis CRCs (p < 0.0001). The optimum cutoff value of the BI ratio for differentiating the T1 CRCs from the Tis CRCs was 1.64, with a sensitivity, specificity, and area under the curve of 90.5 %, 100 %, and 0.974, respectively. Conclusions: We have demonstrated for the first time that quantitatively evaluating the BI can improve the accuracy of diagnosis of early CRC invasion depth.

Original languageEnglish
Pages (from-to)786-794
Number of pages9
JournalJapanese Journal of Radiology
Volume34
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

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Computed Tomographic Colonography
Colorectal Neoplasms
Computer-Assisted Image Processing
Enema
Area Under Curve
Air
Sensitivity and Specificity
Radiologists

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Diagnosis of early colorectal cancer invasion depth by quantitative evaluation of the basal indentation in CT colonography. / Miyasaka, Mitsutoshi; Tsurumaru, Daisuke; Nishimuta, Yusuke; Asayama, Yoshiki; Kawanami, Satoshi; Oki, Eiji; Hirahashi, Minako; Honda, Hiroshi.

In: Japanese Journal of Radiology, Vol. 34, No. 12, 01.12.2016, p. 786-794.

Research output: Contribution to journalArticle

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abstract = "Objective: To investigate the feasibility of diagnosing the invasion depth of early colorectal cancer (CRC) by quantitatively evaluating the basal indentation (BI)—i.e., the intestinal lateral deformity—in CT colonography (CTC). Materials and methods: 34 early CRCs (13 Tis CRCs and 21 T1 CRCs) in 32 patients who underwent a preoperative CTC were retrospectively examined. Two radiologists calculated the depth of the BI on a computed tomographic air-contrast enema (CT enema) image, the depth of the BI due to the geometric function (BI-G) on a cross-sectional multiplanar reconstruction (CS-MPR) image, and the ratio of the BI to the BI-G (i.e., the “BI ratio”) for each lesion. The BI ratios of the Tis and T1 CRCs were compared. Results: The BI ratios were significantly higher in the T1 CRCs than in the Tis CRCs (p < 0.0001). The optimum cutoff value of the BI ratio for differentiating the T1 CRCs from the Tis CRCs was 1.64, with a sensitivity, specificity, and area under the curve of 90.5 {\%}, 100 {\%}, and 0.974, respectively. Conclusions: We have demonstrated for the first time that quantitatively evaluating the BI can improve the accuracy of diagnosis of early CRC invasion depth.",
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AU - Miyasaka, Mitsutoshi

AU - Tsurumaru, Daisuke

AU - Nishimuta, Yusuke

AU - Asayama, Yoshiki

AU - Kawanami, Satoshi

AU - Oki, Eiji

AU - Hirahashi, Minako

AU - Honda, Hiroshi

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