Diagnostic factors in gastric cardia cancer invading the esophagus

Yoshihiko Maehara, Ikuo Takahashi, Toshiro Okuyama, Hiroyuki Orita, Hideo Baba, Hideaki Anai, Keizo Sugimachi

Research output: Contribution to journalArticle

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Abstract

Background. The prognosis of patients with tumors in the upper one‐third of the stomach, particularly those with esophageal invasion, is poor. Methods. This study involved 168 patients with advanced cancer in the upper third of the stomach whose lesion had had invaded the esophagus. Clinical and pathologic studies were performed with respect to diagnostic factors and histologic differentiation of the lesion. Results. Eighty‐three patients (49.4%) had differentiated gastric cancer, and 85 (50.6%) had undifferentiated cancer. The survival time was shorter for patients with undifferentiated cancer than for those with differentiated cancer (P < 0.01). Multivariate analysis showed operative curability, liver metastasis, peritoneal dissemination, lymph node metastasis, serosal invasion, and tumor size to be independent prognostic factors. In patients with undifferentiated cancer, tumors were larger, serosal invasion was prominent, lymph node metastasis was present in 85.9% of cases, 64.7% of metastases were non‐curatively resected, and survival time was less favorable. Conclusions. Our analysis shows that a group of patients at increased risk for tumor advancement will benefit from more aggressive therapy.

Original languageEnglish
Pages (from-to)302-305
Number of pages4
JournalCancer
Volume71
Issue number2
DOIs
Publication statusPublished - Jan 15 1993

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Cardia
Esophageal Neoplasms
Stomach Neoplasms
Neoplasms
Neoplasm Metastasis
Stomach
Lymph Nodes
Survival
Esophagus
Multivariate Analysis
Liver

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Maehara, Y., Takahashi, I., Okuyama, T., Orita, H., Baba, H., Anai, H., & Sugimachi, K. (1993). Diagnostic factors in gastric cardia cancer invading the esophagus. Cancer, 71(2), 302-305. https://doi.org/10.1002/1097-0142(19930115)71:2<302::AID-CNCR2820710206>3.0.CO;2-R

Diagnostic factors in gastric cardia cancer invading the esophagus. / Maehara, Yoshihiko; Takahashi, Ikuo; Okuyama, Toshiro; Orita, Hiroyuki; Baba, Hideo; Anai, Hideaki; Sugimachi, Keizo.

In: Cancer, Vol. 71, No. 2, 15.01.1993, p. 302-305.

Research output: Contribution to journalArticle

Maehara, Y, Takahashi, I, Okuyama, T, Orita, H, Baba, H, Anai, H & Sugimachi, K 1993, 'Diagnostic factors in gastric cardia cancer invading the esophagus', Cancer, vol. 71, no. 2, pp. 302-305. https://doi.org/10.1002/1097-0142(19930115)71:2<302::AID-CNCR2820710206>3.0.CO;2-R
Maehara, Yoshihiko ; Takahashi, Ikuo ; Okuyama, Toshiro ; Orita, Hiroyuki ; Baba, Hideo ; Anai, Hideaki ; Sugimachi, Keizo. / Diagnostic factors in gastric cardia cancer invading the esophagus. In: Cancer. 1993 ; Vol. 71, No. 2. pp. 302-305.
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N2 - Background. The prognosis of patients with tumors in the upper one‐third of the stomach, particularly those with esophageal invasion, is poor. Methods. This study involved 168 patients with advanced cancer in the upper third of the stomach whose lesion had had invaded the esophagus. Clinical and pathologic studies were performed with respect to diagnostic factors and histologic differentiation of the lesion. Results. Eighty‐three patients (49.4%) had differentiated gastric cancer, and 85 (50.6%) had undifferentiated cancer. The survival time was shorter for patients with undifferentiated cancer than for those with differentiated cancer (P < 0.01). Multivariate analysis showed operative curability, liver metastasis, peritoneal dissemination, lymph node metastasis, serosal invasion, and tumor size to be independent prognostic factors. In patients with undifferentiated cancer, tumors were larger, serosal invasion was prominent, lymph node metastasis was present in 85.9% of cases, 64.7% of metastases were non‐curatively resected, and survival time was less favorable. Conclusions. Our analysis shows that a group of patients at increased risk for tumor advancement will benefit from more aggressive therapy.

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