Diagnostic performance of apparent diffusion coefficient for predicting histological grade of hepatocellular carcinoma

Akihiro Nishie, Tsuyoshi Tajima, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Akinobu Taketomi, Kengo Yoshimitsu, Hiroshi Honda

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Abstract

Objective: To investigate whether the histological grade of hepatocellular carcinoma (HCC) can be predicted using the apparent diffusion coefficient (ADC). Materials and Methods: This retrospective study group consisted of 80 patients with 85 surgically resected HCCs who underwent preoperative MRI exams including diffusion-weighted imaging. The tumors were histologically classified into five groups as follows: five well (w-), 17 well to moderately (wm-), 37 moderately (m-), 16 moderately to poorly (mp-), and 10 poorly (p-) differentiated HCCs. For ADC measurement of each HCC, the largest possible region of interest was placed on the solid region on the ADC map where ADC was considered to be the lowest. The average ADCs of the five histological grades were compared using Spearman's rank correlation test and Student's t-test, and the diagnostic performance of ADC for mp- and p-HCCs was also evaluated using a receiver operating characteristic-based positive test. Results: The average ADC of p-HCC (0.76 ± 0.10 × 10 -3 mm 2/s) was significantly lower than those of the other four histological grades. The average ADC of mp-HCCs (0.99 ± 0.20 × 10 -3 mm 2/s) was significantly lower than those of w-, wm- and m-HCCs. The sensitivity, specificity, PPV, NPV, and accuracy, when an ADC of 0.972 or lower was considered an indicator of mp- and p-HCCs, were 73.1%, 72.9%, 54.3%, 86.0% and 72.9%, respectively. Conclusion: ADCs of mp- and p-HCCs were lower than those of w-, wm- and m-HCCs. ADC can contribute to radiological diagnosis of poorly differentiated components in HCCs.

Original languageEnglish
Pages (from-to)e29-e33
JournalEuropean Journal of Radiology
Volume80
Issue number2
DOIs
Publication statusPublished - Nov 1 2011

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Hepatocellular Carcinoma
Routine Diagnostic Tests
ROC Curve
Retrospective Studies
Students
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Diagnostic performance of apparent diffusion coefficient for predicting histological grade of hepatocellular carcinoma. / Nishie, Akihiro; Tajima, Tsuyoshi; Asayama, Yoshiki; Ishigami, Kousei; Kakihara, Daisuke; Nakayama, Tomohiro; Takayama, Yukihisa; Okamoto, Daisuke; Fujita, Nobuhiro; Taketomi, Akinobu; Yoshimitsu, Kengo; Honda, Hiroshi.

In: European Journal of Radiology, Vol. 80, No. 2, 01.11.2011, p. e29-e33.

Research output: Contribution to journalArticle

Nishie, Akihiro ; Tajima, Tsuyoshi ; Asayama, Yoshiki ; Ishigami, Kousei ; Kakihara, Daisuke ; Nakayama, Tomohiro ; Takayama, Yukihisa ; Okamoto, Daisuke ; Fujita, Nobuhiro ; Taketomi, Akinobu ; Yoshimitsu, Kengo ; Honda, Hiroshi. / Diagnostic performance of apparent diffusion coefficient for predicting histological grade of hepatocellular carcinoma. In: European Journal of Radiology. 2011 ; Vol. 80, No. 2. pp. e29-e33.
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abstract = "Objective: To investigate whether the histological grade of hepatocellular carcinoma (HCC) can be predicted using the apparent diffusion coefficient (ADC). Materials and Methods: This retrospective study group consisted of 80 patients with 85 surgically resected HCCs who underwent preoperative MRI exams including diffusion-weighted imaging. The tumors were histologically classified into five groups as follows: five well (w-), 17 well to moderately (wm-), 37 moderately (m-), 16 moderately to poorly (mp-), and 10 poorly (p-) differentiated HCCs. For ADC measurement of each HCC, the largest possible region of interest was placed on the solid region on the ADC map where ADC was considered to be the lowest. The average ADCs of the five histological grades were compared using Spearman's rank correlation test and Student's t-test, and the diagnostic performance of ADC for mp- and p-HCCs was also evaluated using a receiver operating characteristic-based positive test. Results: The average ADC of p-HCC (0.76 ± 0.10 × 10 -3 mm 2/s) was significantly lower than those of the other four histological grades. The average ADC of mp-HCCs (0.99 ± 0.20 × 10 -3 mm 2/s) was significantly lower than those of w-, wm- and m-HCCs. The sensitivity, specificity, PPV, NPV, and accuracy, when an ADC of 0.972 or lower was considered an indicator of mp- and p-HCCs, were 73.1{\%}, 72.9{\%}, 54.3{\%}, 86.0{\%} and 72.9{\%}, respectively. Conclusion: ADCs of mp- and p-HCCs were lower than those of w-, wm- and m-HCCs. ADC can contribute to radiological diagnosis of poorly differentiated components in HCCs.",
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AU - Tajima, Tsuyoshi

AU - Asayama, Yoshiki

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AU - Kakihara, Daisuke

AU - Nakayama, Tomohiro

AU - Takayama, Yukihisa

AU - Okamoto, Daisuke

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AU - Taketomi, Akinobu

AU - Yoshimitsu, Kengo

AU - Honda, Hiroshi

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AB - Objective: To investigate whether the histological grade of hepatocellular carcinoma (HCC) can be predicted using the apparent diffusion coefficient (ADC). Materials and Methods: This retrospective study group consisted of 80 patients with 85 surgically resected HCCs who underwent preoperative MRI exams including diffusion-weighted imaging. The tumors were histologically classified into five groups as follows: five well (w-), 17 well to moderately (wm-), 37 moderately (m-), 16 moderately to poorly (mp-), and 10 poorly (p-) differentiated HCCs. For ADC measurement of each HCC, the largest possible region of interest was placed on the solid region on the ADC map where ADC was considered to be the lowest. The average ADCs of the five histological grades were compared using Spearman's rank correlation test and Student's t-test, and the diagnostic performance of ADC for mp- and p-HCCs was also evaluated using a receiver operating characteristic-based positive test. Results: The average ADC of p-HCC (0.76 ± 0.10 × 10 -3 mm 2/s) was significantly lower than those of the other four histological grades. The average ADC of mp-HCCs (0.99 ± 0.20 × 10 -3 mm 2/s) was significantly lower than those of w-, wm- and m-HCCs. The sensitivity, specificity, PPV, NPV, and accuracy, when an ADC of 0.972 or lower was considered an indicator of mp- and p-HCCs, were 73.1%, 72.9%, 54.3%, 86.0% and 72.9%, respectively. Conclusion: ADCs of mp- and p-HCCs were lower than those of w-, wm- and m-HCCs. ADC can contribute to radiological diagnosis of poorly differentiated components in HCCs.

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