Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas

Teppei Aso, Ohtsuka Takao, Noboru Ideno, Hiroshi Kono, Yosuke Nagayoshi, Yasuhisa Mori, Kenoki Ouchida, Junji Ueda, Shunnichi Takahata, Katsuya Morimatsu, Shinichi Aishima, Hisato Igarashi, Tetsuhide Ito, Kosei Ishigami, Kazuhiro Mizumoto, Masao Tanaka

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: A dilated orifice of the duodenal papilla found during screening endoscopy or ERCP is well-known as one of the specific findings of intraductal papillary mucinous neoplasm (IPMN). However, its clinical significance is still unclear. Objective: To assess the diagnostic significance of a dilated orifice of the duodenal papilla and evaluate whether this could be a factor predictive of malignancy or a subtype of IPMN. Design: Retrospective study. Setting: University hospital. Patients: This study involved 149 patients who underwent pancreatectomy for IPMN between January 1987 and June 2011. Intervention: ERCP. Main Outcome Measurements: The rate of malignant and intestinal type IPMNs in patients with and without papillary dilation. Results: A dilated orifice of the duodenal papilla was significantly associated with intestinal type IPMN (P <.001), but this finding could not predict the malignant grade of IPMN (P =.13). Multivariate analysis revealed that a dilated orifice was a significant factor for predicting intestinal type in both main duct (P =.01) and branch duct IPMNs (P <.001). Limitations: The validity of the definition of papillary dilation, selection bias, and a retrospective study. Conclusion: A dilated orifice of the duodenal papilla could be a significant factor for predicting intestinal type IPMN. This may lead to better clinical management of patients with IPMN.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalGastrointestinal endoscopy
Volume76
Issue number2
DOIs
Publication statusPublished - Aug 1 2012

Fingerprint

Pancreatic Neoplasms
Neoplasms
Endoscopic Retrograde Cholangiopancreatography
Dilatation
Retrospective Studies
Pancreatectomy
Selection Bias
Endoscopy
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas. / Aso, Teppei; Takao, Ohtsuka; Ideno, Noboru; Kono, Hiroshi; Nagayoshi, Yosuke; Mori, Yasuhisa; Ouchida, Kenoki; Ueda, Junji; Takahata, Shunnichi; Morimatsu, Katsuya; Aishima, Shinichi; Igarashi, Hisato; Ito, Tetsuhide; Ishigami, Kosei; Mizumoto, Kazuhiro; Tanaka, Masao.

In: Gastrointestinal endoscopy, Vol. 76, No. 2, 01.08.2012, p. 313-320.

Research output: Contribution to journalArticle

Aso, T, Takao, O, Ideno, N, Kono, H, Nagayoshi, Y, Mori, Y, Ouchida, K, Ueda, J, Takahata, S, Morimatsu, K, Aishima, S, Igarashi, H, Ito, T, Ishigami, K, Mizumoto, K & Tanaka, M 2012, 'Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas', Gastrointestinal endoscopy, vol. 76, no. 2, pp. 313-320. https://doi.org/10.1016/j.gie.2012.03.682
Aso, Teppei ; Takao, Ohtsuka ; Ideno, Noboru ; Kono, Hiroshi ; Nagayoshi, Yosuke ; Mori, Yasuhisa ; Ouchida, Kenoki ; Ueda, Junji ; Takahata, Shunnichi ; Morimatsu, Katsuya ; Aishima, Shinichi ; Igarashi, Hisato ; Ito, Tetsuhide ; Ishigami, Kosei ; Mizumoto, Kazuhiro ; Tanaka, Masao. / Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas. In: Gastrointestinal endoscopy. 2012 ; Vol. 76, No. 2. pp. 313-320.
@article{8492dbe39f4b4533a10942ad739e9a09,
title = "Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas",
abstract = "Background: A dilated orifice of the duodenal papilla found during screening endoscopy or ERCP is well-known as one of the specific findings of intraductal papillary mucinous neoplasm (IPMN). However, its clinical significance is still unclear. Objective: To assess the diagnostic significance of a dilated orifice of the duodenal papilla and evaluate whether this could be a factor predictive of malignancy or a subtype of IPMN. Design: Retrospective study. Setting: University hospital. Patients: This study involved 149 patients who underwent pancreatectomy for IPMN between January 1987 and June 2011. Intervention: ERCP. Main Outcome Measurements: The rate of malignant and intestinal type IPMNs in patients with and without papillary dilation. Results: A dilated orifice of the duodenal papilla was significantly associated with intestinal type IPMN (P <.001), but this finding could not predict the malignant grade of IPMN (P =.13). Multivariate analysis revealed that a dilated orifice was a significant factor for predicting intestinal type in both main duct (P =.01) and branch duct IPMNs (P <.001). Limitations: The validity of the definition of papillary dilation, selection bias, and a retrospective study. Conclusion: A dilated orifice of the duodenal papilla could be a significant factor for predicting intestinal type IPMN. This may lead to better clinical management of patients with IPMN.",
author = "Teppei Aso and Ohtsuka Takao and Noboru Ideno and Hiroshi Kono and Yosuke Nagayoshi and Yasuhisa Mori and Kenoki Ouchida and Junji Ueda and Shunnichi Takahata and Katsuya Morimatsu and Shinichi Aishima and Hisato Igarashi and Tetsuhide Ito and Kosei Ishigami and Kazuhiro Mizumoto and Masao Tanaka",
year = "2012",
month = "8",
day = "1",
doi = "10.1016/j.gie.2012.03.682",
language = "English",
volume = "76",
pages = "313--320",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Diagnostic significance of a dilated orifice of the duodenal papilla in intraductal papillary mucinous neoplasm of the pancreas

AU - Aso, Teppei

AU - Takao, Ohtsuka

AU - Ideno, Noboru

AU - Kono, Hiroshi

AU - Nagayoshi, Yosuke

AU - Mori, Yasuhisa

AU - Ouchida, Kenoki

AU - Ueda, Junji

AU - Takahata, Shunnichi

AU - Morimatsu, Katsuya

AU - Aishima, Shinichi

AU - Igarashi, Hisato

AU - Ito, Tetsuhide

AU - Ishigami, Kosei

AU - Mizumoto, Kazuhiro

AU - Tanaka, Masao

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Background: A dilated orifice of the duodenal papilla found during screening endoscopy or ERCP is well-known as one of the specific findings of intraductal papillary mucinous neoplasm (IPMN). However, its clinical significance is still unclear. Objective: To assess the diagnostic significance of a dilated orifice of the duodenal papilla and evaluate whether this could be a factor predictive of malignancy or a subtype of IPMN. Design: Retrospective study. Setting: University hospital. Patients: This study involved 149 patients who underwent pancreatectomy for IPMN between January 1987 and June 2011. Intervention: ERCP. Main Outcome Measurements: The rate of malignant and intestinal type IPMNs in patients with and without papillary dilation. Results: A dilated orifice of the duodenal papilla was significantly associated with intestinal type IPMN (P <.001), but this finding could not predict the malignant grade of IPMN (P =.13). Multivariate analysis revealed that a dilated orifice was a significant factor for predicting intestinal type in both main duct (P =.01) and branch duct IPMNs (P <.001). Limitations: The validity of the definition of papillary dilation, selection bias, and a retrospective study. Conclusion: A dilated orifice of the duodenal papilla could be a significant factor for predicting intestinal type IPMN. This may lead to better clinical management of patients with IPMN.

AB - Background: A dilated orifice of the duodenal papilla found during screening endoscopy or ERCP is well-known as one of the specific findings of intraductal papillary mucinous neoplasm (IPMN). However, its clinical significance is still unclear. Objective: To assess the diagnostic significance of a dilated orifice of the duodenal papilla and evaluate whether this could be a factor predictive of malignancy or a subtype of IPMN. Design: Retrospective study. Setting: University hospital. Patients: This study involved 149 patients who underwent pancreatectomy for IPMN between January 1987 and June 2011. Intervention: ERCP. Main Outcome Measurements: The rate of malignant and intestinal type IPMNs in patients with and without papillary dilation. Results: A dilated orifice of the duodenal papilla was significantly associated with intestinal type IPMN (P <.001), but this finding could not predict the malignant grade of IPMN (P =.13). Multivariate analysis revealed that a dilated orifice was a significant factor for predicting intestinal type in both main duct (P =.01) and branch duct IPMNs (P <.001). Limitations: The validity of the definition of papillary dilation, selection bias, and a retrospective study. Conclusion: A dilated orifice of the duodenal papilla could be a significant factor for predicting intestinal type IPMN. This may lead to better clinical management of patients with IPMN.

UR - http://www.scopus.com/inward/record.url?scp=84864115161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864115161&partnerID=8YFLogxK

U2 - 10.1016/j.gie.2012.03.682

DO - 10.1016/j.gie.2012.03.682

M3 - Article

VL - 76

SP - 313

EP - 320

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 2

ER -