TY - JOUR
T1 - Diagnostic value of FDG-PET/CT for the identification of extranodal extension in patients with head and neck squamous cell carcinoma
AU - Toya, Ryo
AU - Saito, Tetsuo
AU - Matsuyama, Tomohiko
AU - Kai, Yudai
AU - Shiraishi, Shinya
AU - Murakami, Daizo
AU - Yoshida, Ryoji
AU - Watakabe, Takahiro
AU - Sakamoto, Fumi
AU - Tsuda, Noriko
AU - Arimura, Hidetaka
AU - Orita, Yorihisa
AU - Nakayama, Hideki
AU - Oya, Natsuo
N1 - Funding Information:
This work was supported by the JSPS KAKENHI (grant number 18K07758).
Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - Background/Aim: We evaluated the diagnostic value of functional imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) for the identification of extranodal extension (ENE) in patients with head and neck squamous cell carcinoma (HNSCC). Patients and Methods: In this study, 94 patients with HNSCC who underwent FDG-PET/CT were enrolled. We recorded the maximum standardized uptake value (SUVmax), compared the results with pathologic findings, and evaluated the diagnostic performance of using a SUVmax cut-off value for ENE. Results: Of the 566 dissected levels examined, 53 (9.4%) exhibited ENE. The mean SUVmax of LN with and without ENE were 6.67 and 1.64, respectively (p<0.001). A receiver operating characteristics (ROC) curve analysis for SUVmax showed an area under the ROC curve of 0.913. A SUVmax cutoff of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. Conclusion: FDG-PET/CT findings using a SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE.
AB - Background/Aim: We evaluated the diagnostic value of functional imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) for the identification of extranodal extension (ENE) in patients with head and neck squamous cell carcinoma (HNSCC). Patients and Methods: In this study, 94 patients with HNSCC who underwent FDG-PET/CT were enrolled. We recorded the maximum standardized uptake value (SUVmax), compared the results with pathologic findings, and evaluated the diagnostic performance of using a SUVmax cut-off value for ENE. Results: Of the 566 dissected levels examined, 53 (9.4%) exhibited ENE. The mean SUVmax of LN with and without ENE were 6.67 and 1.64, respectively (p<0.001). A receiver operating characteristics (ROC) curve analysis for SUVmax showed an area under the ROC curve of 0.913. A SUVmax cutoff of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. Conclusion: FDG-PET/CT findings using a SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE.
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U2 - 10.21873/anticanres.14165
DO - 10.21873/anticanres.14165
M3 - Article
C2 - 32234899
AN - SCOPUS:85082731445
SN - 0250-7005
VL - 40
SP - 2073
EP - 2077
JO - Anticancer Research
JF - Anticancer Research
IS - 4
ER -
