Diagnostic value of serum procalcitonin and C-reactive protein for infections after allogeneic hematopoietic stem cell transplantation versus nontransplant setting

Yasuo Mori, Kohta Miyawaki, Koji Kato, Katsuto Takenaka, Hiromi Iwasaki, Naoki Harada, Toshihiro Miyamoto, Koichi Akashi, Takanori Teshima

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective Procalcitonin (PCT) has been increasingly used as a biomarker of infection. The purpose of this study was to evaluate its diagnostic value after hematopoietic stem cell transplantation (HSCT), where noninfectious febrile complications such as graft-versus-host disease frequently develop. Methods We retrospectively analyzed 144 febrile episodes (infections: 82, and noninfections: 62) in adult patients with hematological disorders, including 57 and 87 episodes in HSCT and non-HSCT patients, respectively. Results Of 57 febrile episodes in HSCT patients, 46 (86%) and 25 (44%) revealed positivity for C-reactive protein (CRP) and PCT, respectively. Among 87 febrile episodes in non-HSCT patients, 81 (93%) and 22 (25%) events showed positive results of CRP and PCT. Both of these biomarkers were associated with infectious episodes in univariate analysis. Multivariate analysis showed that a high cut-off level (>9.5 mg/dL) of CRP was a better indicator for infections than PCT in HSCT patients, while PCT positivity was more diagnostic for infections than any cutoff CRP level in non-HSCT patients. Conclusion It may be necessary to interpret the results of these biomarkers with different orders of priority in transplant versus nontransplant patients.

Original languageEnglish
Pages (from-to)2149-2155
Number of pages7
JournalInternal Medicine
Volume50
Issue number19
DOIs
Publication statusPublished - Oct 11 2011

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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