Diagnostic value of squamous cell change associated with endometrial carcinoma: A cytopathologic approach

Yukie Toomine, Sumiko Watanabe, Setsuo Sugishima, Yoshihiro Ohishi, Sadafumi Tamiya, Hiroaki Kobayashi, Kenzo Sonoda, Yoshinao Oda, Kiyoko Kato, Tsunehisa Kaku

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background To determine the frequency of squamous cell change associated with endometrial carcinoma, to evaluate the relationship between squamous cell change and clinicopathological features, and to assess cytological findings for squamous cells with and without nuclear atypia in endometrial smears. Methods In 103 cases of endometrioid adenocarcinoma of the endometrium having both histological and cytological specimens, the frequencies and relationships between the presence and absence of squamous cell changes were evaluated, as were the clinicopathological features of such changes. In endometrial smears, squamous cells with and without nuclear atypia were clinicopathologically assessed. Results Squamous cell changes were found in 58.3% of cases that had both histological and cytological preparations. There were no significant differences between the group with squamous cell changes and the group without in any of the clinicopathological features. In the cytological smears, 70.0% of the 60 cases that showed squamous cell changes in both preparations did not have nuclear atypia of squamous cells, while 30.0% of those cases had atypia. The group of cases with squamous cells without atypia tended to be better differentiated than the group with atypia. Vessels were permeated significantly more often in the group with atypia than in the group without. Conclusions Our data suggest the importance of observing squamous cells in endometrial cytology, especially concerning findings on nuclei with vs without atypia, when endometrial carcinoma is suspected. Diagn. Cytopathol. 2016;44:187-194.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalDiagnostic Cytopathology
Volume44
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Endometrial Neoplasms
Epithelial Cells
Endometrioid Carcinoma
Endometrium
Cell Biology

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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Diagnostic value of squamous cell change associated with endometrial carcinoma : A cytopathologic approach. / Toomine, Yukie; Watanabe, Sumiko; Sugishima, Setsuo; Ohishi, Yoshihiro; Tamiya, Sadafumi; Kobayashi, Hiroaki; Sonoda, Kenzo; Oda, Yoshinao; Kato, Kiyoko; Kaku, Tsunehisa.

In: Diagnostic Cytopathology, Vol. 44, No. 3, 01.03.2016, p. 187-194.

Research output: Contribution to journalArticle

Toomine, Yukie ; Watanabe, Sumiko ; Sugishima, Setsuo ; Ohishi, Yoshihiro ; Tamiya, Sadafumi ; Kobayashi, Hiroaki ; Sonoda, Kenzo ; Oda, Yoshinao ; Kato, Kiyoko ; Kaku, Tsunehisa. / Diagnostic value of squamous cell change associated with endometrial carcinoma : A cytopathologic approach. In: Diagnostic Cytopathology. 2016 ; Vol. 44, No. 3. pp. 187-194.
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abstract = "Background To determine the frequency of squamous cell change associated with endometrial carcinoma, to evaluate the relationship between squamous cell change and clinicopathological features, and to assess cytological findings for squamous cells with and without nuclear atypia in endometrial smears. Methods In 103 cases of endometrioid adenocarcinoma of the endometrium having both histological and cytological specimens, the frequencies and relationships between the presence and absence of squamous cell changes were evaluated, as were the clinicopathological features of such changes. In endometrial smears, squamous cells with and without nuclear atypia were clinicopathologically assessed. Results Squamous cell changes were found in 58.3{\%} of cases that had both histological and cytological preparations. There were no significant differences between the group with squamous cell changes and the group without in any of the clinicopathological features. In the cytological smears, 70.0{\%} of the 60 cases that showed squamous cell changes in both preparations did not have nuclear atypia of squamous cells, while 30.0{\%} of those cases had atypia. The group of cases with squamous cells without atypia tended to be better differentiated than the group with atypia. Vessels were permeated significantly more often in the group with atypia than in the group without. Conclusions Our data suggest the importance of observing squamous cells in endometrial cytology, especially concerning findings on nuclei with vs without atypia, when endometrial carcinoma is suspected. Diagn. Cytopathol. 2016;44:187-194.",
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AU - Tamiya, Sadafumi

AU - Kobayashi, Hiroaki

AU - Sonoda, Kenzo

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N2 - Background To determine the frequency of squamous cell change associated with endometrial carcinoma, to evaluate the relationship between squamous cell change and clinicopathological features, and to assess cytological findings for squamous cells with and without nuclear atypia in endometrial smears. Methods In 103 cases of endometrioid adenocarcinoma of the endometrium having both histological and cytological specimens, the frequencies and relationships between the presence and absence of squamous cell changes were evaluated, as were the clinicopathological features of such changes. In endometrial smears, squamous cells with and without nuclear atypia were clinicopathologically assessed. Results Squamous cell changes were found in 58.3% of cases that had both histological and cytological preparations. There were no significant differences between the group with squamous cell changes and the group without in any of the clinicopathological features. In the cytological smears, 70.0% of the 60 cases that showed squamous cell changes in both preparations did not have nuclear atypia of squamous cells, while 30.0% of those cases had atypia. The group of cases with squamous cells without atypia tended to be better differentiated than the group with atypia. Vessels were permeated significantly more often in the group with atypia than in the group without. Conclusions Our data suggest the importance of observing squamous cells in endometrial cytology, especially concerning findings on nuclei with vs without atypia, when endometrial carcinoma is suspected. Diagn. Cytopathol. 2016;44:187-194.

AB - Background To determine the frequency of squamous cell change associated with endometrial carcinoma, to evaluate the relationship between squamous cell change and clinicopathological features, and to assess cytological findings for squamous cells with and without nuclear atypia in endometrial smears. Methods In 103 cases of endometrioid adenocarcinoma of the endometrium having both histological and cytological specimens, the frequencies and relationships between the presence and absence of squamous cell changes were evaluated, as were the clinicopathological features of such changes. In endometrial smears, squamous cells with and without nuclear atypia were clinicopathologically assessed. Results Squamous cell changes were found in 58.3% of cases that had both histological and cytological preparations. There were no significant differences between the group with squamous cell changes and the group without in any of the clinicopathological features. In the cytological smears, 70.0% of the 60 cases that showed squamous cell changes in both preparations did not have nuclear atypia of squamous cells, while 30.0% of those cases had atypia. The group of cases with squamous cells without atypia tended to be better differentiated than the group with atypia. Vessels were permeated significantly more often in the group with atypia than in the group without. Conclusions Our data suggest the importance of observing squamous cells in endometrial cytology, especially concerning findings on nuclei with vs without atypia, when endometrial carcinoma is suspected. Diagn. Cytopathol. 2016;44:187-194.

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