Diaminodiphenylmethane Derivatives as a New Chromogenic Hydrogen Donor in Peroxidase-Catalyzed Oxidation Reaction with Hydrogen Peroxide

Makoto Mizoguchi, Masanobu Shiga, Kazumi Sasamoto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

New chromogenic hydrogen donors (la—c) for peroxidase-catalyzed oxidation were synthesized and demonstrated to be potentially useful for spectrometric determination of hydrogen peroxide. Under oxidative conditions these compounds exhibit, without an additional component, intense blue colors at ca. 650 nm with higher sensitivities toward hydrogen peroxide than those of conventional reagents. The detection limit of hydrogen peroxide using these compounds was 0.1 μM under serum-free conditions.

Original languageEnglish
Pages (from-to)620-623
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number3
DOIs
Publication statusPublished - 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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