Diastereoselective construction of the 19-epi-C 18-C 25 segment of (-)-lasonolide A was achieved using a 5-exo-trigonal mode of radical cyclization for the creation of the contiguous quaternary and tertiary stereogenic centers at C 22 and C 23 as the key reaction step. During the dehydration stage, it was found that an unusual inversion of configuration took place.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry