Dichotomous effect of a traditional Japanese medicine, Bu-zhong-yi-qi-tang on allergic asthma in mice

Ryotaro Ishimitsu, Hitoshi Nishimura, Hideyuki Kawauchi, Takuya Kawakita, Yasunobu Yoshikai

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

To determine the potentiality of prophylactic and/or therapeutic approaches using a traditional herbal medicine, Bu-zhong-yi-qi-tang (Japanese name: Hochu-ekki-to, HOT), for the control of allergic disease, we examined the effects of oral administration of HOT on a murine model of asthma allergic responses. When oral administration of HOT was begun at the induction phase immediately after OVA sensitization, eosinophilia and Th2-type cytokine production in the airway were reduced in OVA-sensitized mice following OVA inhalation. The serum levels of OVA-specific immunoglobulin (Ig)E and IgG1 were significantly decreased, whereas the level of OVA-specific IgG2a was increased. Interleukin (IL)-4 production by spleen T cells in response to OVA was significantly suppressed, while Interferon (IFN)-γ production was increased in mice treated with HOT in the induction phase. On the other hand, HOT given in the eliciting phase induced a predominant Th2 response with increased IgE production in OVA-sensitized mice following OVA inhalation. These results suggest that the oral administration of HOT dichotomously modulates allergic inflammation in a murine model for asthma, thus offering a different approach for the treatment of allergic disorders.

Original languageEnglish
Pages (from-to)857-865
Number of pages9
JournalInternational Immunopharmacology
Volume1
Issue number5
DOIs
Publication statusPublished - Apr 21 2001
Externally publishedYes

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Traditional Medicine
Asthma
Oral Administration
Immunoglobulin E
Inhalation
Herbal Medicine
Eosinophilia
bu-zhong-yi-qi-tang
Interleukin-4
Interferons
Names
Spleen
Immunoglobulin G
Cytokines
Inflammation
T-Lymphocytes
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

Cite this

Dichotomous effect of a traditional Japanese medicine, Bu-zhong-yi-qi-tang on allergic asthma in mice. / Ishimitsu, Ryotaro; Nishimura, Hitoshi; Kawauchi, Hideyuki; Kawakita, Takuya; Yoshikai, Yasunobu.

In: International Immunopharmacology, Vol. 1, No. 5, 21.04.2001, p. 857-865.

Research output: Contribution to journalArticle

Ishimitsu, Ryotaro ; Nishimura, Hitoshi ; Kawauchi, Hideyuki ; Kawakita, Takuya ; Yoshikai, Yasunobu. / Dichotomous effect of a traditional Japanese medicine, Bu-zhong-yi-qi-tang on allergic asthma in mice. In: International Immunopharmacology. 2001 ; Vol. 1, No. 5. pp. 857-865.
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