TY - JOUR
T1 - Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice
AU - Yano, Satomi
AU - Umeda, Daisuke
AU - Yamashita, Shuya
AU - Yamada, Koji
AU - Tachibana, Hirofumi
N1 - Funding Information:
Grants: The first author was supported by a fellowship from the Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists.
PY - 2009/11
Y1 - 2009/11
N2 - One of the flavones, apigenin has various physiological functions including anti-inflammatory activities. Atopic dermatitis (AD) is a chronically relapsing inflammatory disorder that is characterized by pruritic and eczematous skin lesions. To evaluate the anti-allergic effect of apigenin in vivo, we examined the effect of dietary apigenin on picrylchloride (PiCl)-induced AD-like pathology in NC/Nga mice. NC/Nga mice were fed experimental diets containing apigenin from Day 18 after sensitized with PiCl for 4 weeks. Dietary apigenin significantly alleviated the development of skin lesions, accompanied by lower serum immunoglobulin (Ig) G1 and IgE levels in NC/Nga mice. Interferon (IFN)-γ mRNA expression level in spleen cells from NC/Nga mice was reduced by apigenin feeding. Moreover, interleukin 4-induced signal transducers and activators of transcription 6 phosphorylation in primary spleen cells from BALB/c mice was inhibited by treatment with apigenin. These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-γ expression in NC/Nga mice.
AB - One of the flavones, apigenin has various physiological functions including anti-inflammatory activities. Atopic dermatitis (AD) is a chronically relapsing inflammatory disorder that is characterized by pruritic and eczematous skin lesions. To evaluate the anti-allergic effect of apigenin in vivo, we examined the effect of dietary apigenin on picrylchloride (PiCl)-induced AD-like pathology in NC/Nga mice. NC/Nga mice were fed experimental diets containing apigenin from Day 18 after sensitized with PiCl for 4 weeks. Dietary apigenin significantly alleviated the development of skin lesions, accompanied by lower serum immunoglobulin (Ig) G1 and IgE levels in NC/Nga mice. Interferon (IFN)-γ mRNA expression level in spleen cells from NC/Nga mice was reduced by apigenin feeding. Moreover, interleukin 4-induced signal transducers and activators of transcription 6 phosphorylation in primary spleen cells from BALB/c mice was inhibited by treatment with apigenin. These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-γ expression in NC/Nga mice.
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U2 - 10.1016/j.jnutbio.2008.08.002
DO - 10.1016/j.jnutbio.2008.08.002
M3 - Article
C2 - 18993046
AN - SCOPUS:71949131567
SN - 0955-2863
VL - 20
SP - 876
EP - 881
JO - Nutrition Reports International
JF - Nutrition Reports International
IS - 11
ER -
