Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice

Satomi Yano, Daisuke Umeda, Shuya Yamashita, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

One of the flavones, apigenin has various physiological functions including anti-inflammatory activities. Atopic dermatitis (AD) is a chronically relapsing inflammatory disorder that is characterized by pruritic and eczematous skin lesions. To evaluate the anti-allergic effect of apigenin in vivo, we examined the effect of dietary apigenin on picrylchloride (PiCl)-induced AD-like pathology in NC/Nga mice. NC/Nga mice were fed experimental diets containing apigenin from Day 18 after sensitized with PiCl for 4 weeks. Dietary apigenin significantly alleviated the development of skin lesions, accompanied by lower serum immunoglobulin (Ig) G1 and IgE levels in NC/Nga mice. Interferon (IFN)-γ mRNA expression level in spleen cells from NC/Nga mice was reduced by apigenin feeding. Moreover, interleukin 4-induced signal transducers and activators of transcription 6 phosphorylation in primary spleen cells from BALB/c mice was inhibited by treatment with apigenin. These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-γ expression in NC/Nga mice.

Original languageEnglish
Pages (from-to)876-881
Number of pages6
JournalJournal of Nutritional Biochemistry
Volume20
Issue number11
DOIs
Publication statusPublished - Nov 1 2009
Externally publishedYes

Fingerprint

Apigenin
Atopic Dermatitis
Skin
Interferons
Immunoglobulin E
Spleen
STAT6 Transcription Factor
Flavones
Anti-Allergic Agents
Phosphorylation
Pathology
Nutrition
Serum
Interleukin-4
Immunoglobulins
Anti-Inflammatory Agents
Diet
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice. / Yano, Satomi; Umeda, Daisuke; Yamashita, Shuya; Yamada, Koji; Tachibana, Hirofumi.

In: Journal of Nutritional Biochemistry, Vol. 20, No. 11, 01.11.2009, p. 876-881.

Research output: Contribution to journalArticle

Yano, Satomi ; Umeda, Daisuke ; Yamashita, Shuya ; Yamada, Koji ; Tachibana, Hirofumi. / Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice. In: Journal of Nutritional Biochemistry. 2009 ; Vol. 20, No. 11. pp. 876-881.
@article{b4c51c7a71a24dfe8b03be1e347e3f33,
title = "Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice",
abstract = "One of the flavones, apigenin has various physiological functions including anti-inflammatory activities. Atopic dermatitis (AD) is a chronically relapsing inflammatory disorder that is characterized by pruritic and eczematous skin lesions. To evaluate the anti-allergic effect of apigenin in vivo, we examined the effect of dietary apigenin on picrylchloride (PiCl)-induced AD-like pathology in NC/Nga mice. NC/Nga mice were fed experimental diets containing apigenin from Day 18 after sensitized with PiCl for 4 weeks. Dietary apigenin significantly alleviated the development of skin lesions, accompanied by lower serum immunoglobulin (Ig) G1 and IgE levels in NC/Nga mice. Interferon (IFN)-γ mRNA expression level in spleen cells from NC/Nga mice was reduced by apigenin feeding. Moreover, interleukin 4-induced signal transducers and activators of transcription 6 phosphorylation in primary spleen cells from BALB/c mice was inhibited by treatment with apigenin. These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-γ expression in NC/Nga mice.",
author = "Satomi Yano and Daisuke Umeda and Shuya Yamashita and Koji Yamada and Hirofumi Tachibana",
year = "2009",
month = "11",
day = "1",
doi = "10.1016/j.jnutbio.2008.08.002",
language = "English",
volume = "20",
pages = "876--881",
journal = "Journal of Nutritional Biochemistry",
issn = "0955-2863",
publisher = "Elsevier Inc.",
number = "11",

}

TY - JOUR

T1 - Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice

AU - Yano, Satomi

AU - Umeda, Daisuke

AU - Yamashita, Shuya

AU - Yamada, Koji

AU - Tachibana, Hirofumi

PY - 2009/11/1

Y1 - 2009/11/1

N2 - One of the flavones, apigenin has various physiological functions including anti-inflammatory activities. Atopic dermatitis (AD) is a chronically relapsing inflammatory disorder that is characterized by pruritic and eczematous skin lesions. To evaluate the anti-allergic effect of apigenin in vivo, we examined the effect of dietary apigenin on picrylchloride (PiCl)-induced AD-like pathology in NC/Nga mice. NC/Nga mice were fed experimental diets containing apigenin from Day 18 after sensitized with PiCl for 4 weeks. Dietary apigenin significantly alleviated the development of skin lesions, accompanied by lower serum immunoglobulin (Ig) G1 and IgE levels in NC/Nga mice. Interferon (IFN)-γ mRNA expression level in spleen cells from NC/Nga mice was reduced by apigenin feeding. Moreover, interleukin 4-induced signal transducers and activators of transcription 6 phosphorylation in primary spleen cells from BALB/c mice was inhibited by treatment with apigenin. These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-γ expression in NC/Nga mice.

AB - One of the flavones, apigenin has various physiological functions including anti-inflammatory activities. Atopic dermatitis (AD) is a chronically relapsing inflammatory disorder that is characterized by pruritic and eczematous skin lesions. To evaluate the anti-allergic effect of apigenin in vivo, we examined the effect of dietary apigenin on picrylchloride (PiCl)-induced AD-like pathology in NC/Nga mice. NC/Nga mice were fed experimental diets containing apigenin from Day 18 after sensitized with PiCl for 4 weeks. Dietary apigenin significantly alleviated the development of skin lesions, accompanied by lower serum immunoglobulin (Ig) G1 and IgE levels in NC/Nga mice. Interferon (IFN)-γ mRNA expression level in spleen cells from NC/Nga mice was reduced by apigenin feeding. Moreover, interleukin 4-induced signal transducers and activators of transcription 6 phosphorylation in primary spleen cells from BALB/c mice was inhibited by treatment with apigenin. These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-γ expression in NC/Nga mice.

UR - http://www.scopus.com/inward/record.url?scp=71949131567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71949131567&partnerID=8YFLogxK

U2 - 10.1016/j.jnutbio.2008.08.002

DO - 10.1016/j.jnutbio.2008.08.002

M3 - Article

C2 - 18993046

AN - SCOPUS:71949131567

VL - 20

SP - 876

EP - 881

JO - Journal of Nutritional Biochemistry

JF - Journal of Nutritional Biochemistry

SN - 0955-2863

IS - 11

ER -