Dietary CLA and DHA modify skin properties in mice

Daichi Oikawa, Tomonori Nakanishi, Yoshinori Nakamura, Yukiko Takahashi, Takaya Yamamoto, Nobuya Shiba, Manabu Tobisa, Tomo Takagi, Hisao Iwamoto, Tetsuya Tachibana, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


This study investigated the influence of PUFA on the properties of mouse skin. Mice (3 wk old) were given free access to oils high in linoleic acid, CLA, or DHA for 4 wk. At the end of the experiment, their skins were compared by both biochemical and histological methods. No significant differences in lipid and collagen contents were detected among treatments, although the FA composition in the skin was altered depending upon the FA composition of the supplemented oils. Electron microscopy revealed that the subcutaneous tissue layers in the CLA and DHA groups were significantly thinner than that in the high linoleic acid group, whereas no differences in the thickness of dermis layers were observed among the three groups. These results suggest that skin properties in mice are readily modified by dietary FA sources within 4 wk of dietary oil supplementation.

Original languageEnglish
Pages (from-to)609-614
Number of pages6
Issue number6
Publication statusPublished - Jun 1 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Cell Biology


Dive into the research topics of 'Dietary CLA and DHA modify skin properties in mice'. Together they form a unique fingerprint.

Cite this