Dietary conjugated linoleic acid increases endurance capacity and fat oxidation in mice during exercise

Wataru Mizunoya, Satoshi Haramizu, Tetsuro Shibakusa, Yuki Okabe, Tohru Fushiki

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Ingestion of CLA activates β-oxidation and causes loss of body fat in rodents. We investigated the effects of dietary CLA on endurance capacity and energy metabolism during exercise in mice. Five-week-old male BALB/c mice were fed a control diet containing 1.0% linoleic acid or a diet containing 0.5% CLA that replaced an equivalent amount of linoleic acid for 1 wk. The maximum swimming time until fatigue was significantly higher in the CLA-fed group than in the control group. During treadmill running, the respiratory exchange ratio was significantly lower in the CLA-fed group, but oxygen consumption did not differ significantly between groups, suggesting that FA contributed more as an energy substrate in the CLA-fed mice. The muscle lipoprotein lipase activity was significantly higher in the CLA-fed group than in the control group. These results suggest that CLA ingestion increases endurance exercise capacity by promoting fat oxidation during exercise.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalLipids
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 1 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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