Dietary conjugated linoleic acid increases immunoglobulin productivity of sprague-dawley rat spleen lymphocytes

Masao Yamasaki, Koji Kishihara, Keiko Mansho, Yuuya Ogino, Masaaki Kasai, Michihiro Sugano, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticle

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Abstract

The dietary effects of conjugated linoleic acid (CLA) on Ig production of Sprague-Dawley rats were examined at various doses such as 0 (control), 0.05, 0.10, 0.25, and 0.50%. CLA increased IgG and IgM production of spleen lymphocytes in a dose-dependent manner, and these levels reached a plateau at 0.25%. IgA production was not detected in the control group, while it was detected in all CLA-fed groups and IgA productivity of spleen lymphocytes increased in a dose-dependent manner at the doses from 0.05 to 0.50%. Dietary CLA did not affect serum Ig levels. The major fatty acid composition of spleen lymphocytes was not affected by dietary CLA, which itself was hardly incorporated into the cells. In an in vitro assay, the effects of CLA and its oxidative derivatives, furan type fatty acids, on Ig productivity were also examined. As a result, 100 μM CLA suppressed Ig production of spleen lymphocytes and the degree was as follows IgA>IgG>IgM. Each CLA isomer and the furan type fatty acids also suppressed Ig production but the degree was weaker than the mixture of CLA isomers. In this result, dietary CLA increased Ig productivity of spleen lymphocytes in vivo.

Original languageEnglish
Pages (from-to)2159-2164
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume64
Issue number10
DOIs
Publication statusPublished - Jan 1 2000

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Conjugated Linoleic Acids
Lymphocytes
Sprague Dawley Rats
Immunoglobulins
Rats
Spleen
Productivity
Immunoglobulin A
Fatty Acids
Isomers
Immunoglobulin M
Immunoglobulin G
Assays
Derivatives

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Dietary conjugated linoleic acid increases immunoglobulin productivity of sprague-dawley rat spleen lymphocytes. / Yamasaki, Masao; Kishihara, Koji; Mansho, Keiko; Ogino, Yuuya; Kasai, Masaaki; Sugano, Michihiro; Tachibana, Hirofumi; Yamada, Koji.

In: Bioscience, Biotechnology and Biochemistry, Vol. 64, No. 10, 01.01.2000, p. 2159-2164.

Research output: Contribution to journalArticle

Yamasaki, Masao ; Kishihara, Koji ; Mansho, Keiko ; Ogino, Yuuya ; Kasai, Masaaki ; Sugano, Michihiro ; Tachibana, Hirofumi ; Yamada, Koji. / Dietary conjugated linoleic acid increases immunoglobulin productivity of sprague-dawley rat spleen lymphocytes. In: Bioscience, Biotechnology and Biochemistry. 2000 ; Vol. 64, No. 10. pp. 2159-2164.
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