Dietary d-allose ameliorates hepatic inflammation in mice with non-alcoholic steatohepatitis

Ryoko Yamamoto, Ayaka Iida, Ken Tanikawa, Hideki Shiratsuchi, Masaaki Tokuda, Toshiro Matsui, Tsuyoshi Nakamura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nonalcoholic steatohepatitis (NASH) is characterized by excess lipid accumulation and inflammation in hepatocytes. In this study, to provide insight into the preventive effects of d-allose, a rare sugar, on the onset of NASH, we designed animal experiments using male STAM mice treated with streptozotocin and fed a high-fat diet (HFD). Experiments were initiated when the mice reached 5 weeks of age and lasted 3 weeks. After the 3-week protocol, mice fed the HFD containing d-allose exhibited significantly decreased serum alanine aminotransferase levels, hepatic lipid accumulation and inflammation, and improved nonalcoholic fatty liver disease activity score compared to mice fed HFD without d-allose ( p < 0.05). Further, hepatic mRNA expression of sterol regulatory element binding protein-1 (Srebp-1) and monocyte chemotactic protein-1 (Mcp-1) was lower in mice fed d-allose. These results suggested that d-allose prevented NASH by blocking hepatic lipid accumulation and progressive inflammation.

Original languageEnglish
Pages (from-to)319-327
Number of pages9
JournalFood Science and Technology Research
Volume23
Issue number2
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing

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