Abstract
D-Allulose, a C-3 epimer of D-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary D-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of D-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% D-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, D-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary D-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, D-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters.
| Original language | English |
|---|---|
| Article number | 103429 |
| Journal | Journal of Functional Foods |
| Volume | 60 |
| DOIs | |
| Publication status | Published - Sep 1 2019 |
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All Science Journal Classification (ASJC) codes
- Food Science
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Dietary D-allulose alters cholesterol metabolism in Golden Syrian hamsters partly by reducing serum PCSK9 levels. / Kanasaki, Akane; Jiang, Zhe; Mizokami, Takuya; Shirouchi, Bungo; Iida, Tetsuo; Nagata, Yasuo; Sato, Masao.
In: Journal of Functional Foods, Vol. 60, 103429, 01.09.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary D-allulose alters cholesterol metabolism in Golden Syrian hamsters partly by reducing serum PCSK9 levels
AU - Kanasaki, Akane
AU - Jiang, Zhe
AU - Mizokami, Takuya
AU - Shirouchi, Bungo
AU - Iida, Tetsuo
AU - Nagata, Yasuo
AU - Sato, Masao
PY - 2019/9/1
Y1 - 2019/9/1
N2 - D-Allulose, a C-3 epimer of D-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary D-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of D-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% D-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, D-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary D-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, D-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters.
AB - D-Allulose, a C-3 epimer of D-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary D-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of D-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% D-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, D-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary D-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, D-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters.
UR - http://www.scopus.com/inward/record.url?scp=85067952974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067952974&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2019.103429
DO - 10.1016/j.jff.2019.103429
M3 - Article
AN - SCOPUS:85067952974
VL - 60
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
M1 - 103429
ER -