Dietary Effect of α-Tocopherol and Tocotrienols on Lipid Metabolism and Immune Function of Aged Sprague-Dawley Rats

Koji Yamada, Masaaki Okabe, Ken Ichi Ohkura, Mariko Qji, Michiko Nonaka, Ikuo Ikeda, Hirofumi Tachibana

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Eight-month-old male Sprague Dawley rats were fed diets containing α-tocopherol (Toc) or tocotrienol (T3) mixture (composed of 20.5% α-Toc, 21.4% α-T3, 36.5% γ-T3 and other analogs) at the 0.1 or 0.5% level for 3 weeks to examine their dietary effects on lipid metabolism and immune indices. Feeding of α-Toc and T3 significantly decreased liver phosphatidylcholine peroxide and serum phospholipid levels. In the regulation of immunoglobulin level, significant increase in serum IgA level was observed in the rats fed α-Toc or T3, but the effect on immunoglobulin productivity from spleen and mesenteric lymph node (MLN) was not as marked. Feeding of α-Toc and T3 significantly decreased LTB4-releasing activity of peritoneal exudate cells without decreasing arachidonic acid level. The suppression of LTB4 release was more marked in the rats fed 0.1% α-Toc or T3 than in these fed them at the 0.5% level. When animals were killed after 10 h of fasting, T3 was detected only in MLN and epidydimal adipose tissue. These results suggest that T3 modulates lipid metabolism and immune functions as well as α-Toc, and that MLN and adipose tissue are the main target tissues of T3.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalFood Science and Technology Research
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 1 2002

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Tocotrienols
tocotrienols
Tocopherols
Lipid Metabolism
tocopherols
lipid metabolism
Sprague Dawley Rats
Rats
Tissue
rats
lymph nodes
Phospholipids
Nutrition
Peroxides
Leukotriene B4
Lymph Nodes
Liver
Animals
immunoglobulins
adipose tissue

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing

Cite this

Dietary Effect of α-Tocopherol and Tocotrienols on Lipid Metabolism and Immune Function of Aged Sprague-Dawley Rats. / Yamada, Koji; Okabe, Masaaki; Ohkura, Ken Ichi; Qji, Mariko; Nonaka, Michiko; Ikeda, Ikuo; Tachibana, Hirofumi.

In: Food Science and Technology Research, Vol. 8, No. 1, 01.01.2002, p. 59-63.

Research output: Contribution to journalArticle

Yamada, Koji ; Okabe, Masaaki ; Ohkura, Ken Ichi ; Qji, Mariko ; Nonaka, Michiko ; Ikeda, Ikuo ; Tachibana, Hirofumi. / Dietary Effect of α-Tocopherol and Tocotrienols on Lipid Metabolism and Immune Function of Aged Sprague-Dawley Rats. In: Food Science and Technology Research. 2002 ; Vol. 8, No. 1. pp. 59-63.
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