Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of sprague-dawley rats

Koji Yamada, Yoko Tokunaga, Atsushi Ikeda, Ken Ichi Ohkura, Soichi Mamiya, Shihoko Kaku, Michihiro Sugano, Hirofumi Tachibana

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The dietary effect of the water-soluble dietary fibers (WSDF), guar gum, partially hydrolyzed guar gum (PHGG), glucomannan, highly methoxylated (HM) pectin, on the serum lipid level and immunoglobulin (Ig) production of Sprague-Dawley rats was compared with that of water-insoluble cellulose. Although serum total cholesterol and triglyceride levels were significantly lower in the rats fed with WSDF than in those fed with cellulose, a decrease in the level of phospholipids was only observed in the rats that had been fed on guar gum or glucomannan. In addition, all WSDF feeding enhanced IgA productivity in the spleen and mesenteric lymph node lymphocytes, although the increase in serum IgA level was only observed in the rats fed on WSDF, and not on PHGG. When mesenteric lymph node lymphocytes were cultured in the presence of various concentrations of guar gum or glucomannan, no significant increase in Ig production was apparent. These data suggest that WSDF indirectly enhanced the Ig production of lymphocytes, and that serum lipid reduction and IgA production-enhancing activities of WSDF were dependent on their molecular sizes.

Original languageEnglish
Pages (from-to)2163-2167
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume63
Issue number12
DOIs
Publication statusPublished - Jan 1 1999

Fingerprint

guar gum
Lipid Metabolism
Dietary Fiber
Sprague Dawley Rats
Rats
Water
Lymphocytes
Immunoglobulin A
Immunoglobulins
Serum
Cellulose
Lymph Nodes
Lipids

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of sprague-dawley rats. / Yamada, Koji; Tokunaga, Yoko; Ikeda, Atsushi; Ohkura, Ken Ichi; Mamiya, Soichi; Kaku, Shihoko; Sugano, Michihiro; Tachibana, Hirofumi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 63, No. 12, 01.01.1999, p. 2163-2167.

Research output: Contribution to journalArticle

Yamada, Koji ; Tokunaga, Yoko ; Ikeda, Atsushi ; Ohkura, Ken Ichi ; Mamiya, Soichi ; Kaku, Shihoko ; Sugano, Michihiro ; Tachibana, Hirofumi. / Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of sprague-dawley rats. In: Bioscience, Biotechnology and Biochemistry. 1999 ; Vol. 63, No. 12. pp. 2163-2167.
@article{a61444f016574e2ba81380b604bee7c1,
title = "Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of sprague-dawley rats",
abstract = "The dietary effect of the water-soluble dietary fibers (WSDF), guar gum, partially hydrolyzed guar gum (PHGG), glucomannan, highly methoxylated (HM) pectin, on the serum lipid level and immunoglobulin (Ig) production of Sprague-Dawley rats was compared with that of water-insoluble cellulose. Although serum total cholesterol and triglyceride levels were significantly lower in the rats fed with WSDF than in those fed with cellulose, a decrease in the level of phospholipids was only observed in the rats that had been fed on guar gum or glucomannan. In addition, all WSDF feeding enhanced IgA productivity in the spleen and mesenteric lymph node lymphocytes, although the increase in serum IgA level was only observed in the rats fed on WSDF, and not on PHGG. When mesenteric lymph node lymphocytes were cultured in the presence of various concentrations of guar gum or glucomannan, no significant increase in Ig production was apparent. These data suggest that WSDF indirectly enhanced the Ig production of lymphocytes, and that serum lipid reduction and IgA production-enhancing activities of WSDF were dependent on their molecular sizes.",
author = "Koji Yamada and Yoko Tokunaga and Atsushi Ikeda and Ohkura, {Ken Ichi} and Soichi Mamiya and Shihoko Kaku and Michihiro Sugano and Hirofumi Tachibana",
year = "1999",
month = "1",
day = "1",
doi = "10.1271/bbb.63.2163",
language = "English",
volume = "63",
pages = "2163--2167",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "12",

}

TY - JOUR

T1 - Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of sprague-dawley rats

AU - Yamada, Koji

AU - Tokunaga, Yoko

AU - Ikeda, Atsushi

AU - Ohkura, Ken Ichi

AU - Mamiya, Soichi

AU - Kaku, Shihoko

AU - Sugano, Michihiro

AU - Tachibana, Hirofumi

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The dietary effect of the water-soluble dietary fibers (WSDF), guar gum, partially hydrolyzed guar gum (PHGG), glucomannan, highly methoxylated (HM) pectin, on the serum lipid level and immunoglobulin (Ig) production of Sprague-Dawley rats was compared with that of water-insoluble cellulose. Although serum total cholesterol and triglyceride levels were significantly lower in the rats fed with WSDF than in those fed with cellulose, a decrease in the level of phospholipids was only observed in the rats that had been fed on guar gum or glucomannan. In addition, all WSDF feeding enhanced IgA productivity in the spleen and mesenteric lymph node lymphocytes, although the increase in serum IgA level was only observed in the rats fed on WSDF, and not on PHGG. When mesenteric lymph node lymphocytes were cultured in the presence of various concentrations of guar gum or glucomannan, no significant increase in Ig production was apparent. These data suggest that WSDF indirectly enhanced the Ig production of lymphocytes, and that serum lipid reduction and IgA production-enhancing activities of WSDF were dependent on their molecular sizes.

AB - The dietary effect of the water-soluble dietary fibers (WSDF), guar gum, partially hydrolyzed guar gum (PHGG), glucomannan, highly methoxylated (HM) pectin, on the serum lipid level and immunoglobulin (Ig) production of Sprague-Dawley rats was compared with that of water-insoluble cellulose. Although serum total cholesterol and triglyceride levels were significantly lower in the rats fed with WSDF than in those fed with cellulose, a decrease in the level of phospholipids was only observed in the rats that had been fed on guar gum or glucomannan. In addition, all WSDF feeding enhanced IgA productivity in the spleen and mesenteric lymph node lymphocytes, although the increase in serum IgA level was only observed in the rats fed on WSDF, and not on PHGG. When mesenteric lymph node lymphocytes were cultured in the presence of various concentrations of guar gum or glucomannan, no significant increase in Ig production was apparent. These data suggest that WSDF indirectly enhanced the Ig production of lymphocytes, and that serum lipid reduction and IgA production-enhancing activities of WSDF were dependent on their molecular sizes.

UR - http://www.scopus.com/inward/record.url?scp=0033252459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033252459&partnerID=8YFLogxK

U2 - 10.1271/bbb.63.2163

DO - 10.1271/bbb.63.2163

M3 - Article

C2 - 10664849

AN - SCOPUS:0033252459

VL - 63

SP - 2163

EP - 2167

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 12

ER -