Dietary effects of porphyran from Porphyra yezoensis on growth and lipid metabolism of Sprague-Dawley rats

Keisuke Tsuge, Masaaki Okabe, Takashi Yoshimura, Toshihisa Sumi, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Effects of porphyran (POR), a sulfated galactan from an edible red alga Porphyra yezoensis (Susabinori), on growth and lipid metabolism were examined using Sprague-Dawley rats fed a cholesterol-free diet. Rats were divided into four dietary groups: those fed diets containing 5% cellulose (control), agar or two types of POR differing in sugar composition and sulfate content (low sulfate content, LS-POR and high sulfate content, HS-POR) for 3 weeks. Ingestion of the diets containing LS- and HS-POR resulted in a significant decrease in food intake and body weight gain relative to the control diet. Renal adipose tissue weight and serum cholesterol level were also significantly lower in the LS-POR group and the HS-POR group than in the other groups. In contrast, agar, which consists of the same sugar components as POR, had no effect on the above-mentioned growth and lipid parameters. Fecal excretion of neutral sterols was markedly enhanced by POR ingestion, suggesting that POR has a potent effect to interfere with the absorption of neutral sterols within the gastrointestinal tract. Fecal excretion of fatty acids and neutral sterols was significantly higher in the LS-POR group than in the HS-POR group, and it was suggested that the ability to interfere with the absorption of cholesterol and fatty acid within the gastrointesitinal tract depends on the sulfation rate of porphyan.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalFood Science and Technology Research
Volume10
Issue number2
DOIs
Publication statusPublished - Jan 1 2004

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Porphyra
Nutrition
Lipid Metabolism
lipid metabolism
Sprague Dawley Rats
Rats
Cholesterol
sterols
sulfates
rats
cholesterol
Growth
Fatty acids
diet
Sugars
excretion
agar
ingestion
fatty acids
sugars

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing

Cite this

Dietary effects of porphyran from Porphyra yezoensis on growth and lipid metabolism of Sprague-Dawley rats. / Tsuge, Keisuke; Okabe, Masaaki; Yoshimura, Takashi; Sumi, Toshihisa; Tachibana, Hirofumi; Yamada, Koji.

In: Food Science and Technology Research, Vol. 10, No. 2, 01.01.2004, p. 147-151.

Research output: Contribution to journalArticle

Tsuge, Keisuke ; Okabe, Masaaki ; Yoshimura, Takashi ; Sumi, Toshihisa ; Tachibana, Hirofumi ; Yamada, Koji. / Dietary effects of porphyran from Porphyra yezoensis on growth and lipid metabolism of Sprague-Dawley rats. In: Food Science and Technology Research. 2004 ; Vol. 10, No. 2. pp. 147-151.
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