Dietary fiber, source foods and colorectal cancer risk: The Fukuoka colorectal cancer study

Kazuhiro Uchida, Suminori Kono, Guang Yin, Kengo Toyomura, Jun Nagano, Tetsuya Mizoue, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya, Reiji Terasaka

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective. Despite much evidence from laboratory work, epidemiological evidence remains elusive regarding the role of dietary fiber in colorectal carcinogenesis. We investigated associations of dietary fiber and source foods with colorectal cancer risk in the Fukuoka Colorectal Cancer Study, a community-based casecontrol study. Material and methods. The study subjects were 816 incident cases of colorectal cancer and 815 community controls. Nutrient and food intakes were estimated on the basis of a computer-assisted interview regarding 148 dietary items. Odds ratios of colorectal cancer according to quintile categories of energy-adjusted intakes of dietary fiber and food groups were obtained with adjustment for non-dietary factors and dietary intakes of calcium and n-3 fatty acids. Results. Total, soluble and insoluble dietary fibers were not measurably associated with overall risk or subsite-specific risk of colorectal cancer. By contrast, rice consumption was associated with a decreased risk of colorectal cancer (trend p 0.03), particularly of distal colon and rectal cancer (trend p 0.02), and high intake of non-rice cereals tended to be related to an increased risk of colon cancer (trend p 0.07). There was no association between vegetable consumption and colorectal cancer, whereas individuals with the lowest intake of fruits tended to have an increased risk of colorectal cancer. Conclusions. The present study did not corroborate a protective association between dietary fiber and colorectal cancer, but suggested a decreased risk of distal colorectal cancer associated with rice consumption.

Original languageEnglish
Pages (from-to)1223-1231
Number of pages9
JournalScandinavian Journal of Gastroenterology
Volume45
Issue number10
DOIs
Publication statusPublished - Oct 1 2010

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Dietary Fiber
Colorectal Neoplasms
Food
Colonic Neoplasms
Dietary Calcium
Omega-3 Fatty Acids
Rectal Neoplasms
Energy Intake
Vegetables
Fruit
Carcinogenesis
Eating
Odds Ratio
Interviews

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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Dietary fiber, source foods and colorectal cancer risk : The Fukuoka colorectal cancer study. / Uchida, Kazuhiro; Kono, Suminori; Yin, Guang; Toyomura, Kengo; Nagano, Jun; Mizoue, Tetsuya; Mibu, Ryuichi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Takeshi; Ikejiri, Koji; Futami, Kitaroh; Maekawa, Takafumi; Yasunami, Yohichi; Takenaka, Kenji; Ichimiya, Hitoshi; Terasaka, Reiji.

In: Scandinavian Journal of Gastroenterology, Vol. 45, No. 10, 01.10.2010, p. 1223-1231.

Research output: Contribution to journalArticle

Uchida, K, Kono, S, Yin, G, Toyomura, K, Nagano, J, Mizoue, T, Mibu, R, Tanaka, M, Kakeji, Y, Maehara, Y, Okamura, T, Ikejiri, K, Futami, K, Maekawa, T, Yasunami, Y, Takenaka, K, Ichimiya, H & Terasaka, R 2010, 'Dietary fiber, source foods and colorectal cancer risk: The Fukuoka colorectal cancer study', Scandinavian Journal of Gastroenterology, vol. 45, no. 10, pp. 1223-1231. https://doi.org/10.3109/00365521.2010.492528
Uchida, Kazuhiro ; Kono, Suminori ; Yin, Guang ; Toyomura, Kengo ; Nagano, Jun ; Mizoue, Tetsuya ; Mibu, Ryuichi ; Tanaka, Masao ; Kakeji, Yoshihiro ; Maehara, Yoshihiko ; Okamura, Takeshi ; Ikejiri, Koji ; Futami, Kitaroh ; Maekawa, Takafumi ; Yasunami, Yohichi ; Takenaka, Kenji ; Ichimiya, Hitoshi ; Terasaka, Reiji. / Dietary fiber, source foods and colorectal cancer risk : The Fukuoka colorectal cancer study. In: Scandinavian Journal of Gastroenterology. 2010 ; Vol. 45, No. 10. pp. 1223-1231.
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AU - Uchida, Kazuhiro

AU - Kono, Suminori

AU - Yin, Guang

AU - Toyomura, Kengo

AU - Nagano, Jun

AU - Mizoue, Tetsuya

AU - Mibu, Ryuichi

AU - Tanaka, Masao

AU - Kakeji, Yoshihiro

AU - Maehara, Yoshihiko

AU - Okamura, Takeshi

AU - Ikejiri, Koji

AU - Futami, Kitaroh

AU - Maekawa, Takafumi

AU - Yasunami, Yohichi

AU - Takenaka, Kenji

AU - Ichimiya, Hitoshi

AU - Terasaka, Reiji

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Objective. Despite much evidence from laboratory work, epidemiological evidence remains elusive regarding the role of dietary fiber in colorectal carcinogenesis. We investigated associations of dietary fiber and source foods with colorectal cancer risk in the Fukuoka Colorectal Cancer Study, a community-based casecontrol study. Material and methods. The study subjects were 816 incident cases of colorectal cancer and 815 community controls. Nutrient and food intakes were estimated on the basis of a computer-assisted interview regarding 148 dietary items. Odds ratios of colorectal cancer according to quintile categories of energy-adjusted intakes of dietary fiber and food groups were obtained with adjustment for non-dietary factors and dietary intakes of calcium and n-3 fatty acids. Results. Total, soluble and insoluble dietary fibers were not measurably associated with overall risk or subsite-specific risk of colorectal cancer. By contrast, rice consumption was associated with a decreased risk of colorectal cancer (trend p 0.03), particularly of distal colon and rectal cancer (trend p 0.02), and high intake of non-rice cereals tended to be related to an increased risk of colon cancer (trend p 0.07). There was no association between vegetable consumption and colorectal cancer, whereas individuals with the lowest intake of fruits tended to have an increased risk of colorectal cancer. Conclusions. The present study did not corroborate a protective association between dietary fiber and colorectal cancer, but suggested a decreased risk of distal colorectal cancer associated with rice consumption.

AB - Objective. Despite much evidence from laboratory work, epidemiological evidence remains elusive regarding the role of dietary fiber in colorectal carcinogenesis. We investigated associations of dietary fiber and source foods with colorectal cancer risk in the Fukuoka Colorectal Cancer Study, a community-based casecontrol study. Material and methods. The study subjects were 816 incident cases of colorectal cancer and 815 community controls. Nutrient and food intakes were estimated on the basis of a computer-assisted interview regarding 148 dietary items. Odds ratios of colorectal cancer according to quintile categories of energy-adjusted intakes of dietary fiber and food groups were obtained with adjustment for non-dietary factors and dietary intakes of calcium and n-3 fatty acids. Results. Total, soluble and insoluble dietary fibers were not measurably associated with overall risk or subsite-specific risk of colorectal cancer. By contrast, rice consumption was associated with a decreased risk of colorectal cancer (trend p 0.03), particularly of distal colon and rectal cancer (trend p 0.02), and high intake of non-rice cereals tended to be related to an increased risk of colon cancer (trend p 0.07). There was no association between vegetable consumption and colorectal cancer, whereas individuals with the lowest intake of fruits tended to have an increased risk of colorectal cancer. Conclusions. The present study did not corroborate a protective association between dietary fiber and colorectal cancer, but suggested a decreased risk of distal colorectal cancer associated with rice consumption.

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