Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan: The Osaka Maternal and Child Health Study

Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Tetsuji Yokoyama, Yukihiro Ohya, Wakaba Fukushima, Kyoko Saito, Satoko Ohfuji, Chikako Kiyohara, Yoshio Hirota

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Previous studies showed an inverse association between folate intake and depression. However, epidemiological evidence for folate intake and postpartum depression is unavailable. This prospective study examined the relationship of dietary consumption of folate and B vitamins during pregnancy with the risk of postpartum depression. Methods: Study subjects were 865 Japanese women. Dietary data were obtained during pregnancy from a validated self-administered diet history questionnaire. Postpartum depression was defined as present when subjects had an Edinburgh Postnatal Depression Scale score of 9 or higher between 2 and 9 months postpartum. Adjustment was made for age, gestation, parity, cigarette smoking, alcohol intake, family structure, family income, education, changes in diet in the previous 1 month, season when data at baseline were collected, body mass index, time of delivery before the second survey, medical problems in pregnancy, baby's sex, and baby's birth weight. Results: Postpartum depression developed in 121 subjects (14.0%) 2 to 9 months postpartum. There was no measurable association between intake of folate, cobalamin, or pyridoxine and the risk of postpartum depression. Compared with riboflavin intake in the first quartile, only riboflavin consumption in the third quartile was independently related to a decreased risk of postpartum depression (multivariate odds ratio: 0.53, 95% CI: 0.29-0.95, P for trend = 0.55). Limitations: Personal and family psychiatric history, sociocultural factors, and personal and family relations were not controlled for. The possibility of misclassification of dietary information during pregnancy should be considered. Conclusions: Our results suggest that moderate consumption of riboflavin may be protective against postpartum depression.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of Affective Disorders
Volume96
Issue number1-2
DOIs
Publication statusPublished - Nov 1 2006
Externally publishedYes

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Postpartum Depression
Vitamin B 6
Riboflavin
Vitamin B 12
Folic Acid
Japan
Pregnancy
Postpartum Period
Diet
Social Adjustment
Vitamin B Complex
Pyridoxine
Maternal Health
Child Health
Family Relations
Parity
Birth Weight
Psychiatry
Body Mass Index
Smoking

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan : The Osaka Maternal and Child Health Study. / Miyake, Yoshihiro; Sasaki, Satoshi; Tanaka, Keiko; Yokoyama, Tetsuji; Ohya, Yukihiro; Fukushima, Wakaba; Saito, Kyoko; Ohfuji, Satoko; Kiyohara, Chikako; Hirota, Yoshio.

In: Journal of Affective Disorders, Vol. 96, No. 1-2, 01.11.2006, p. 133-138.

Research output: Contribution to journalArticle

Miyake, Yoshihiro ; Sasaki, Satoshi ; Tanaka, Keiko ; Yokoyama, Tetsuji ; Ohya, Yukihiro ; Fukushima, Wakaba ; Saito, Kyoko ; Ohfuji, Satoko ; Kiyohara, Chikako ; Hirota, Yoshio. / Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan : The Osaka Maternal and Child Health Study. In: Journal of Affective Disorders. 2006 ; Vol. 96, No. 1-2. pp. 133-138.
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T1 - Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan

T2 - The Osaka Maternal and Child Health Study

AU - Miyake, Yoshihiro

AU - Sasaki, Satoshi

AU - Tanaka, Keiko

AU - Yokoyama, Tetsuji

AU - Ohya, Yukihiro

AU - Fukushima, Wakaba

AU - Saito, Kyoko

AU - Ohfuji, Satoko

AU - Kiyohara, Chikako

AU - Hirota, Yoshio

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N2 - Background: Previous studies showed an inverse association between folate intake and depression. However, epidemiological evidence for folate intake and postpartum depression is unavailable. This prospective study examined the relationship of dietary consumption of folate and B vitamins during pregnancy with the risk of postpartum depression. Methods: Study subjects were 865 Japanese women. Dietary data were obtained during pregnancy from a validated self-administered diet history questionnaire. Postpartum depression was defined as present when subjects had an Edinburgh Postnatal Depression Scale score of 9 or higher between 2 and 9 months postpartum. Adjustment was made for age, gestation, parity, cigarette smoking, alcohol intake, family structure, family income, education, changes in diet in the previous 1 month, season when data at baseline were collected, body mass index, time of delivery before the second survey, medical problems in pregnancy, baby's sex, and baby's birth weight. Results: Postpartum depression developed in 121 subjects (14.0%) 2 to 9 months postpartum. There was no measurable association between intake of folate, cobalamin, or pyridoxine and the risk of postpartum depression. Compared with riboflavin intake in the first quartile, only riboflavin consumption in the third quartile was independently related to a decreased risk of postpartum depression (multivariate odds ratio: 0.53, 95% CI: 0.29-0.95, P for trend = 0.55). Limitations: Personal and family psychiatric history, sociocultural factors, and personal and family relations were not controlled for. The possibility of misclassification of dietary information during pregnancy should be considered. Conclusions: Our results suggest that moderate consumption of riboflavin may be protective against postpartum depression.

AB - Background: Previous studies showed an inverse association between folate intake and depression. However, epidemiological evidence for folate intake and postpartum depression is unavailable. This prospective study examined the relationship of dietary consumption of folate and B vitamins during pregnancy with the risk of postpartum depression. Methods: Study subjects were 865 Japanese women. Dietary data were obtained during pregnancy from a validated self-administered diet history questionnaire. Postpartum depression was defined as present when subjects had an Edinburgh Postnatal Depression Scale score of 9 or higher between 2 and 9 months postpartum. Adjustment was made for age, gestation, parity, cigarette smoking, alcohol intake, family structure, family income, education, changes in diet in the previous 1 month, season when data at baseline were collected, body mass index, time of delivery before the second survey, medical problems in pregnancy, baby's sex, and baby's birth weight. Results: Postpartum depression developed in 121 subjects (14.0%) 2 to 9 months postpartum. There was no measurable association between intake of folate, cobalamin, or pyridoxine and the risk of postpartum depression. Compared with riboflavin intake in the first quartile, only riboflavin consumption in the third quartile was independently related to a decreased risk of postpartum depression (multivariate odds ratio: 0.53, 95% CI: 0.29-0.95, P for trend = 0.55). Limitations: Personal and family psychiatric history, sociocultural factors, and personal and family relations were not controlled for. The possibility of misclassification of dietary information during pregnancy should be considered. Conclusions: Our results suggest that moderate consumption of riboflavin may be protective against postpartum depression.

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