Dietary Garcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake

Daichi Oikawa, Hachidai Hirakawa, Kohsuke Hayamizu, Yoshinori Nakamura, Nobuya Shiba, Tomonori Nakanishi, Hisao Iwamoto, Tetsuya Tachibana, Mitsuhiro Furuse

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The influence of 3.3% Garcinia cambogia extract on the properties of mouse skin with or without 10% sucrose water loading was investigated. Mice (7-week-old) were given free access to a control diet or a diet containing Garcinia cambogia extract. They were also given water alone or both water and sucrose water. Their skin was compared by both biochemical and histological methods. The collagen and triacylglycerol contents were not significantly different among the four groups. Similarly, electron microscopy revealed no differences in the thickness of the dermis layer or the subcutaneous tissue layer. Mice given the diet containing Garcinia cambogia tended to have a reduced total number of adipocytes, but not significantly. These results suggest that Garcinia cambogia supplementation for at least 4 weeks does not induce a negative effect on skin properties in mice irrespective of excessive sucrose intake.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalPhytotherapy Research
Issue number4
Publication statusPublished - Apr 1 2005


All Science Journal Classification (ASJC) codes

  • Pharmacology

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