Dietary glycemic index is inversely associated with the risk of Parkinson's disease: A case-control study in Japan

Kentaro Murakami, Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Wakaba Fukushima, Chikako Kiyohara, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Takami Miki, Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota, Masaki Nagai

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31 Citations (Scopus)

Abstract

Objective: High glycemic index (GI) or glycemic load (GL) carbohydrates might be expected to decrease the risk of Parkinson's disease (PD) by an insulin-induced increase in brain dopamine. We conducted a hospital-based case-control study in Japan to examine associations between dietary GI and GL and other dietary carbohydrate variables, including intake of available carbohydrate and dietary fiber, and PD. Methods: Patients with PD diagnosed using the U.K. Parkinson's Disease Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semiquantitative, comprehensive diet history questionnaire. Results: After adjustment for potential dietary and non-dietary confounding factors, dietary GI was significantly inversely associated with the risk of PD. Multivariate odds ratios (95% confidence intervals) for PD in the first, second, third, and fourth quartiles of dietary GI were 1.00 (reference), 1.03 (0.64-1.66), 0.68 (0.41-1.15), and 0.61 (0.34-1.09), respectively (P for trend=0.04). Conversely, no significant association was observed for other dietary carbohydrates, including dietary GL (P for trend=0.77), available carbohydrate intake (P for trend=0.28), or dietary fiber intake (P for trend=0.73). Conclusion: This preliminary case-control study based on current dietary habits found an independent inverse relation between dietary GI and PD. Considering the plausibility of the putative mechanism, further investigation using a case-control design with accurate assessment of past dietary habits or a prospective design is warranted.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalNutrition
Volume26
Issue number5
DOIs
Publication statusPublished - May 1 2010

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Glycemic Index
Parkinson Disease
Case-Control Studies
Japan
Dietary Carbohydrates
Carbohydrates
Dietary Fiber
Feeding Behavior
Time and Motion Studies
Brain
Neurodegenerative Diseases
Dopamine
Odds Ratio
Confidence Intervals
Insulin
Diet

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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Dietary glycemic index is inversely associated with the risk of Parkinson's disease : A case-control study in Japan. / Murakami, Kentaro; Miyake, Yoshihiro; Sasaki, Satoshi; Tanaka, Keiko; Fukushima, Wakaba; Kiyohara, Chikako; Tsuboi, Yoshio; Yamada, Tatsuo; Oeda, Tomoko; Miki, Takami; Kawamura, Nobutoshi; Sakae, Nobutaka; Fukuyama, Hidenao; Hirota, Yoshio; Nagai, Masaki.

In: Nutrition, Vol. 26, No. 5, 01.05.2010, p. 515-521.

Research output: Contribution to journalArticle

Murakami, K, Miyake, Y, Sasaki, S, Tanaka, K, Fukushima, W, Kiyohara, C, Tsuboi, Y, Yamada, T, Oeda, T, Miki, T, Kawamura, N, Sakae, N, Fukuyama, H, Hirota, Y & Nagai, M 2010, 'Dietary glycemic index is inversely associated with the risk of Parkinson's disease: A case-control study in Japan', Nutrition, vol. 26, no. 5, pp. 515-521. https://doi.org/10.1016/j.nut.2009.05.021
Murakami, Kentaro ; Miyake, Yoshihiro ; Sasaki, Satoshi ; Tanaka, Keiko ; Fukushima, Wakaba ; Kiyohara, Chikako ; Tsuboi, Yoshio ; Yamada, Tatsuo ; Oeda, Tomoko ; Miki, Takami ; Kawamura, Nobutoshi ; Sakae, Nobutaka ; Fukuyama, Hidenao ; Hirota, Yoshio ; Nagai, Masaki. / Dietary glycemic index is inversely associated with the risk of Parkinson's disease : A case-control study in Japan. In: Nutrition. 2010 ; Vol. 26, No. 5. pp. 515-521.
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abstract = "Objective: High glycemic index (GI) or glycemic load (GL) carbohydrates might be expected to decrease the risk of Parkinson's disease (PD) by an insulin-induced increase in brain dopamine. We conducted a hospital-based case-control study in Japan to examine associations between dietary GI and GL and other dietary carbohydrate variables, including intake of available carbohydrate and dietary fiber, and PD. Methods: Patients with PD diagnosed using the U.K. Parkinson's Disease Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semiquantitative, comprehensive diet history questionnaire. Results: After adjustment for potential dietary and non-dietary confounding factors, dietary GI was significantly inversely associated with the risk of PD. Multivariate odds ratios (95{\%} confidence intervals) for PD in the first, second, third, and fourth quartiles of dietary GI were 1.00 (reference), 1.03 (0.64-1.66), 0.68 (0.41-1.15), and 0.61 (0.34-1.09), respectively (P for trend=0.04). Conversely, no significant association was observed for other dietary carbohydrates, including dietary GL (P for trend=0.77), available carbohydrate intake (P for trend=0.28), or dietary fiber intake (P for trend=0.73). Conclusion: This preliminary case-control study based on current dietary habits found an independent inverse relation between dietary GI and PD. Considering the plausibility of the putative mechanism, further investigation using a case-control design with accurate assessment of past dietary habits or a prospective design is warranted.",
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T1 - Dietary glycemic index is inversely associated with the risk of Parkinson's disease

T2 - A case-control study in Japan

AU - Murakami, Kentaro

AU - Miyake, Yoshihiro

AU - Sasaki, Satoshi

AU - Tanaka, Keiko

AU - Fukushima, Wakaba

AU - Kiyohara, Chikako

AU - Tsuboi, Yoshio

AU - Yamada, Tatsuo

AU - Oeda, Tomoko

AU - Miki, Takami

AU - Kawamura, Nobutoshi

AU - Sakae, Nobutaka

AU - Fukuyama, Hidenao

AU - Hirota, Yoshio

AU - Nagai, Masaki

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Objective: High glycemic index (GI) or glycemic load (GL) carbohydrates might be expected to decrease the risk of Parkinson's disease (PD) by an insulin-induced increase in brain dopamine. We conducted a hospital-based case-control study in Japan to examine associations between dietary GI and GL and other dietary carbohydrate variables, including intake of available carbohydrate and dietary fiber, and PD. Methods: Patients with PD diagnosed using the U.K. Parkinson's Disease Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semiquantitative, comprehensive diet history questionnaire. Results: After adjustment for potential dietary and non-dietary confounding factors, dietary GI was significantly inversely associated with the risk of PD. Multivariate odds ratios (95% confidence intervals) for PD in the first, second, third, and fourth quartiles of dietary GI were 1.00 (reference), 1.03 (0.64-1.66), 0.68 (0.41-1.15), and 0.61 (0.34-1.09), respectively (P for trend=0.04). Conversely, no significant association was observed for other dietary carbohydrates, including dietary GL (P for trend=0.77), available carbohydrate intake (P for trend=0.28), or dietary fiber intake (P for trend=0.73). Conclusion: This preliminary case-control study based on current dietary habits found an independent inverse relation between dietary GI and PD. Considering the plausibility of the putative mechanism, further investigation using a case-control design with accurate assessment of past dietary habits or a prospective design is warranted.

AB - Objective: High glycemic index (GI) or glycemic load (GL) carbohydrates might be expected to decrease the risk of Parkinson's disease (PD) by an insulin-induced increase in brain dopamine. We conducted a hospital-based case-control study in Japan to examine associations between dietary GI and GL and other dietary carbohydrate variables, including intake of available carbohydrate and dietary fiber, and PD. Methods: Patients with PD diagnosed using the U.K. Parkinson's Disease Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semiquantitative, comprehensive diet history questionnaire. Results: After adjustment for potential dietary and non-dietary confounding factors, dietary GI was significantly inversely associated with the risk of PD. Multivariate odds ratios (95% confidence intervals) for PD in the first, second, third, and fourth quartiles of dietary GI were 1.00 (reference), 1.03 (0.64-1.66), 0.68 (0.41-1.15), and 0.61 (0.34-1.09), respectively (P for trend=0.04). Conversely, no significant association was observed for other dietary carbohydrates, including dietary GL (P for trend=0.77), available carbohydrate intake (P for trend=0.28), or dietary fiber intake (P for trend=0.73). Conclusion: This preliminary case-control study based on current dietary habits found an independent inverse relation between dietary GI and PD. Considering the plausibility of the putative mechanism, further investigation using a case-control design with accurate assessment of past dietary habits or a prospective design is warranted.

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