Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults

Makiko Abe, Nitin Shivappa, Hidemi Ito, Isao Oze, Tetsuya Abe, Yasuhiro Shimizu, Yasuhisa Hasegawa, Chikako Kiyohara, Masatoshi Nomura, Yoshihiro Ogawa, James R. Hebert, Keitaro Matsuo

Research output: Contribution to journalArticle

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Abstract

Background: The inflammatory potential of diet that has been shown to be associated with cancer risk. We examined the association between dietary inflammatory potential as measured by the dietary inflammatory index (DII®) and risk of upper aerodigestive tract cancers in a Japanese case-control study. Results: A positive association was observed between increasing DII scores and overall upper aerodigestive tract cancers, and across anatomic subsites. For upper aerodigestive tract cancers, the ORQ4vsQ1 = 1.73 (95% CI: 1.37-2.20); head and neck cancer, the ORQ4vsQ1 was 1.92 (95% CI: 1.42-2.59); and for esophageal cancer, the ORQ4vsQ1 was1.71 (95% CI: 1.54-1.90). Risks for hypopharyngeal and nasopharyngeal cancers were greatly elevated: (ORQ4vsQ1 = 4.05 (95% CI: 1.24-13.25) for hypopharyngeal cancer and ORQ4vsQ1 = 4.99 (95% CI: 1.14-21.79) for nasopharyngeal cancer. Conclusion: A more pro-inflammatory diet was associated with an elevated risk of upper aerodigestive tract cancers after accounting for important confounders. All anatomic subsites, except larynx, showed the consistently elevated risk with increasing DII score. Those subsites with known etiological associations with persistent infection showed the largest elevation in risk. These results warrant further evaluation in future studies. Materials and Methods: This is a case-control study of 1,028 cases and 3,081 age- and sex-matched non-cancer controls recruited at Aichi Cancer Center. DII scores were computed based on estimates of macro- and micro-nutrients from a self-administered food frequency questionnaire. Scores were further categorized into quartiles (based on the distribution in controls). Conditional logistic regression models were fit to estimate odds ratio (OR) and 95% confidence intervals (CIs) adjusted for smoking, ethanol consumption, alcohol flushing, number of teeth, and occupation group.

Original languageEnglish
Pages (from-to)24028-24040
Number of pages13
JournalOncotarget
Volume9
Issue number35
DOIs
Publication statusPublished - May 1 2018

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Confidence Intervals
Hypopharyngeal Neoplasms
Nasopharyngeal Neoplasms
Neoplasms
Food
Case-Control Studies
Logistic Models
Diet
Esophageal Neoplasms
Head and Neck Neoplasms
Larynx
Occupations
Alcohol Drinking
Tooth
Ethanol
Smoking
Odds Ratio
Infection

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Abe, M., Shivappa, N., Ito, H., Oze, I., Abe, T., Shimizu, Y., ... Matsuo, K. (2018). Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults. Oncotarget, 9(35), 24028-24040. https://doi.org/10.18632/oncotarget.25288

Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults. / Abe, Makiko; Shivappa, Nitin; Ito, Hidemi; Oze, Isao; Abe, Tetsuya; Shimizu, Yasuhiro; Hasegawa, Yasuhisa; Kiyohara, Chikako; Nomura, Masatoshi; Ogawa, Yoshihiro; Hebert, James R.; Matsuo, Keitaro.

In: Oncotarget, Vol. 9, No. 35, 01.05.2018, p. 24028-24040.

Research output: Contribution to journalArticle

Abe, M, Shivappa, N, Ito, H, Oze, I, Abe, T, Shimizu, Y, Hasegawa, Y, Kiyohara, C, Nomura, M, Ogawa, Y, Hebert, JR & Matsuo, K 2018, 'Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults', Oncotarget, vol. 9, no. 35, pp. 24028-24040. https://doi.org/10.18632/oncotarget.25288
Abe, Makiko ; Shivappa, Nitin ; Ito, Hidemi ; Oze, Isao ; Abe, Tetsuya ; Shimizu, Yasuhiro ; Hasegawa, Yasuhisa ; Kiyohara, Chikako ; Nomura, Masatoshi ; Ogawa, Yoshihiro ; Hebert, James R. ; Matsuo, Keitaro. / Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults. In: Oncotarget. 2018 ; Vol. 9, No. 35. pp. 24028-24040.
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AU - Shimizu, Yasuhiro

AU - Hasegawa, Yasuhisa

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