Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults

Kentaro Murakami, Tetsuya Mizoue, Satoshi Sasaki, Masanori Ohta, Masao Sato, Yumi Matsushita, Norio Mishima

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Objective: Although a favorable effect of dietary folate and ω-3 polyunsaturated fatty acids (PUFAs) on depression is suggested from epidemiologic studies in Western countries, evidence from non-Western populations is lacking. We examined cross-sectional associations between the intake of folate, other B vitamins, and ω-3 PUFAs and depressive symptoms in Japanese adults. Methods: Subjects were 309 Japanese men and 208 Japanese women 21-67 y of age. Dietary intake was assessed with a validated, brief, self-administered diet history questionnaire. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression scale score ≥16. Adjustment was made for age, body mass index, work place, marital status, occupational physical activity, leisure-time physical activity, current smoking, current alcohol drinking, and job stress score. Results: The prevalences of depressive symptoms were 36% for men and 37% for women. Folate intake showed a statistically significant, inverse, and linear association with depressive symptoms in men but not in women. The multivariate odds ratios (95% confidence intervals) for depressive symptoms for men in the first, second, third, and fourth quartiles of folate intake were 1.00 (reference), 0.78 (0.38-1.63), 0.57 (0.27-1.18), and 0.50 (0.23-1.06), respectively (P for trend = 0.045). No statistically significant linear association was observed for the intake of riboflavin, pyridoxine, cobalamin, total ω-3 PUFAs, α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid in either sex. Conclusion: Higher dietary intake of folate was associated with a lower prevalence of depressive symptoms in Japanese men but not women.

Original languageEnglish
Pages (from-to)140-147
Number of pages8
JournalNutrition
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 1 2008

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Niacinamide
Unsaturated Fatty Acids
Folic Acid
Depression
Epidemiologic Studies
Exercise
Social Adjustment
Pyridoxine
alpha-Linolenic Acid
Eicosapentaenoic Acid
Riboflavin
Docosahexaenoic Acids
Leisure Activities
Marital Status
Vitamin B 12
Workplace
Alcohol Drinking
Body Mass Index
Smoking
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. / Murakami, Kentaro; Mizoue, Tetsuya; Sasaki, Satoshi; Ohta, Masanori; Sato, Masao; Matsushita, Yumi; Mishima, Norio.

In: Nutrition, Vol. 24, No. 2, 01.02.2008, p. 140-147.

Research output: Contribution to journalArticle

Murakami, Kentaro ; Mizoue, Tetsuya ; Sasaki, Satoshi ; Ohta, Masanori ; Sato, Masao ; Matsushita, Yumi ; Mishima, Norio. / Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. In: Nutrition. 2008 ; Vol. 24, No. 2. pp. 140-147.
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T1 - Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults

AU - Murakami, Kentaro

AU - Mizoue, Tetsuya

AU - Sasaki, Satoshi

AU - Ohta, Masanori

AU - Sato, Masao

AU - Matsushita, Yumi

AU - Mishima, Norio

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N2 - Objective: Although a favorable effect of dietary folate and ω-3 polyunsaturated fatty acids (PUFAs) on depression is suggested from epidemiologic studies in Western countries, evidence from non-Western populations is lacking. We examined cross-sectional associations between the intake of folate, other B vitamins, and ω-3 PUFAs and depressive symptoms in Japanese adults. Methods: Subjects were 309 Japanese men and 208 Japanese women 21-67 y of age. Dietary intake was assessed with a validated, brief, self-administered diet history questionnaire. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression scale score ≥16. Adjustment was made for age, body mass index, work place, marital status, occupational physical activity, leisure-time physical activity, current smoking, current alcohol drinking, and job stress score. Results: The prevalences of depressive symptoms were 36% for men and 37% for women. Folate intake showed a statistically significant, inverse, and linear association with depressive symptoms in men but not in women. The multivariate odds ratios (95% confidence intervals) for depressive symptoms for men in the first, second, third, and fourth quartiles of folate intake were 1.00 (reference), 0.78 (0.38-1.63), 0.57 (0.27-1.18), and 0.50 (0.23-1.06), respectively (P for trend = 0.045). No statistically significant linear association was observed for the intake of riboflavin, pyridoxine, cobalamin, total ω-3 PUFAs, α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid in either sex. Conclusion: Higher dietary intake of folate was associated with a lower prevalence of depressive symptoms in Japanese men but not women.

AB - Objective: Although a favorable effect of dietary folate and ω-3 polyunsaturated fatty acids (PUFAs) on depression is suggested from epidemiologic studies in Western countries, evidence from non-Western populations is lacking. We examined cross-sectional associations between the intake of folate, other B vitamins, and ω-3 PUFAs and depressive symptoms in Japanese adults. Methods: Subjects were 309 Japanese men and 208 Japanese women 21-67 y of age. Dietary intake was assessed with a validated, brief, self-administered diet history questionnaire. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression scale score ≥16. Adjustment was made for age, body mass index, work place, marital status, occupational physical activity, leisure-time physical activity, current smoking, current alcohol drinking, and job stress score. Results: The prevalences of depressive symptoms were 36% for men and 37% for women. Folate intake showed a statistically significant, inverse, and linear association with depressive symptoms in men but not in women. The multivariate odds ratios (95% confidence intervals) for depressive symptoms for men in the first, second, third, and fourth quartiles of folate intake were 1.00 (reference), 0.78 (0.38-1.63), 0.57 (0.27-1.18), and 0.50 (0.23-1.06), respectively (P for trend = 0.045). No statistically significant linear association was observed for the intake of riboflavin, pyridoxine, cobalamin, total ω-3 PUFAs, α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid in either sex. Conclusion: Higher dietary intake of folate was associated with a lower prevalence of depressive symptoms in Japanese men but not women.

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